ReviewCurrent opinion in pediatrics2018
Neonatal abstinence syndrome: an update.
Review in Current opinion in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Neurodevelopmental outcomes of prenatal opioid exposure and neonatal opioid withdrawal syndrome: A systematic review from birth to early adulthood.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Design, implementation, and evaluation of neonatal abstinence syndrome care management web application: a multimethod study.Scientific reports · 2026Trial
- Social justice with harm reduction approaches for mothers who use opioids: an international comparative ethnographic study with community engaged methods.Harm reduction journal · 2025Article
- Epigenome-wide association study of placental co-methylated regions in newborns for prenatal opioid exposure.Environmental epigenetics · 2025Article
- Perceptions of substance use disorder in rural areas: how the brain disease model impacts public stigma.BMC public health · 2024Article
- Neonatal Abstinence Syndrome and Corresponding Pharmacotherapy Approaches from 2 University-affiliated Neonatal Intensive Care Units in Puerto Rico (2018-2020).Puerto Rico health sciences journal · 2024Article
- Inpatient Growth in Infants Requiring Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome.International journal of pediatrics · 2024Article
- Infants, children, and youth in foster care with prenatal substance exposure: a synthesis of two scoping reviews.International journal of developmental disabilities · 2023Article
- Length of Stay Among Infants with Neonatal Abstinence Syndrome and Risk of Hospital Readmission.Maternal and child health journal · 2022Article
- Global research production in neonatal abstinence syndrome: A bibliometric analysis.World journal of clinical pediatrics · 2022Article
- Hospital Outcomes of Infants with Neonatal Opioid Withdrawal Syndrome at a Tertiary Care Hospital with High Rates of Concurrent Nonopioid (Polysubstance) Exposure.American journal of perinatology · 2022Article
- Opioid use in pregnancy: An emerging health crisis.Obstetric medicine · 2021Review
- Pharmacometric dose optimization of buprenorphine in neonatal opioid withdrawal syndrome.Clinical and translational science · 2021Article
- Shifting the care paradigm for opioid-exposed newborns in Southern Colorado.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers.Research on child and adolescent psychopathology · 2021Article
- Neonatal opioid exposure: public health crisis and novel neuroinflammatory disease.Neural regeneration research · 2021Review
- Article
- Evaluating Definitions for Neonatal Abstinence Syndrome.Pediatrics · 2021Article
- Evaluating the effect of hospital setting on outcomes for neonatal abstinence syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients.Journal of clinical pharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe current review provides an update focused on the evolving epidemiology of neonatal abstinence syndrome (NAS), factors influencing disease expression, advances in clinical assessment of withdrawal, novel approaches to NAS treatment, and the emerging role of quality improvement in assessment and management of NAS. RECENT
findingsThe rise in the incidence of NAS disproportionately occurred in rural and suburban areas. Polysubstance exposure and genetic polymorphisms have been shown to modify NAS expression and severity. New bedside assessments using a limited number of factors to identify infants with NAS result in fewer infants receiving pharmacotherapy. In addition, buprenorphine may be a promising therapeutic alternative to morphine to treat NAS. Lastly, local, state, and national quality improvement initiatives have emerged as an effective mechanism to advance the care of infants with NAS. SUMMARY: NAS remains a critical public health issue associated with significant medical, economic, and personal burdens. Emerging data on associated risk factors, assessment of and treatment for NAS provide clinicians and hospitals with new knowledge and an urgency to promote standardization of care for infants with NAS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.