Evidence map›Paper›PMID 29346002›Full record

ArticleAmerican journal of public health2018

Intermittent Preventive Therapy in Pregnancy and Incidence of Low Birth Weight in Malaria-Endemic Countries.

Jordan E Cates, Daniel Westreich, Holger W Unger, Melissa Bauserman, Linda Adair, Stephen R Cole, Steven Meshnick, Stephen J Rogerson, Maternal Malaria and Malnutrition (M3) Initiative

Abstract read
In one paragraph

Article in American journal of public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordan E CatesJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Daniel WestreichJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Holger W UngerJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Melissa BausermanJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Linda AdairJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Stephen R ColeJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Steven MeshnickJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Stephen J RogersonJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.
Maternal Malaria and Malnutrition (M3) InitiativeJordan E. Cates, Daniel Westreich, Stephen R. Cole, and Steven Meshnick are with the Department of Epidemiology, University of North Carolina-Chapel Hill (UNC). Holger W. Unger is with the Department of Medicine at the Doherty Institute, The University of Melbourne, Parkville, Victoria, Australia. Melissa Bauserman is with the Department of Pediatrics, Division of Neonatal-Perinatal Medicine, School of Medicine, UNC. Linda Adair is with the Department of Nutrition, UNC. Stephen J. Rogerson is with the Department of Medicine at the Doherty Institute, The University of Melbourne.

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
NIAID NIH HHS T32 AI070114NICHD NIH HHS P2C HD050924Wellcome Trust
6 · The paper itself

Abstract

objectivesTo estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW).

methodsWe analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC.

resultsWe estimated that, compared with observed IPTp use, administering 3 or more doses of IPTp to all women would decrease the incidence of LBW from 9.9% to 6.9% (risk difference = 3.0%; 95% confidence interval = 1.7%, 4.0%). The intervention effects for eliminating malaria at delivery, increasing bed net ownership, and decreasing low MUAC prevalence were all modest.

conclusionsIncreasing IPTp uptake to at least 3 doses could decrease the incidence of LBW in malaria-endemic countries. The impact of IPTp on LBW was greater than the effect of prevention of malaria, consistent with a nonmalarial effect of IPTp, measurement error, or selection bias.

Indexed as

Birth WeightAfricaAntimalarialsFemaleHumansMalariaMalnutritionPregnancyPyrimethamineSulfadoxineAntimalarialsPyrimethamineSulfadoxine

Identifiers

PMID29346002
PMCPMC5803815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.