Evidence map›Paper›PMID 29345968›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Mature gastric chief cells are not required for the development of metaplasia.

Hiroto Kinoshita, Yoku Hayakawa, Zhengchuan Niu, Mitsuru Konishi, Masahiro Hata, Mayo Tsuboi, Yuki Hayata, Yohko Hikiba, Sozaburo Ihara, Hayato Nakagawa and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Gastric Stem Cell Biology and Helicobacter pylori Infection.Current topics in microbiology and immunology · 2023
    Article
  11. Review
  12. Article
  13. Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer.Journal of personalized medicine · 2022
    Review
  14. Article
  15. Article
  16. Gastric epithelial histology and precancerous conditions.World journal of gastrointestinal oncology · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Hiroto KinoshitaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.ORCID 0000-0002-3988-2499
Zhengchuan NiuDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University , New York, New York.
Mitsuru KonishiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Masahiro HataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Mayo TsuboiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Yuki HayataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Yohko HikibaDivision of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation , Tokyo , Japan.
Sozaburo IharaDivision of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation , Tokyo , Japan.
Hayato NakagawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Yoshihiro HirataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University , New York, New York.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo , Tokyo , Japan.
The University of Tokyo · JPThe Institute of Medical Science, Asahi Life Foundation · JPColumbia University · USSun Yat-sen University · CN

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
NCI NIH HHS R35 CA210088
6 · The paper itself

Abstract

During human gastric carcinogenesis, intestinal metaplasia is frequently seen in the atrophic stomach. In mice, a distinct type of metaplasia known as spasmolytic polypeptide-expressing metaplasia (SPEM) is found in several inflammatory and genetically engineered models. Given the diversity of long- and short-term models of mouse SPEM, it remains unclear whether all models have a shared or distinct molecular mechanism. The origin of SPEM in mice is presently under debate. It is postulated that stem or progenitor cells acquire genetic alterations that then supply metaplastic cell clones, whereas the possibility of transdifferentiation or dedifferentiation from mature gastric chief cells has also been suggested. In this study, we report that loss of chief cells was sufficient to induce short-term regenerative SPEM-like lesions that originated from chief cell precursors in the gastric neck region. Furthermore, Lgr5

Indexed as

CarcinogenesisChief Cells, GastricStomach NeoplasmsAnimalsCell LineageCell TransdifferentiationHumansIntercellular Signaling Peptides and ProteinsMetaplasiaMicePeptidesPrecancerous ConditionsReceptors, G-Protein-CoupledIntercellular Signaling Peptides and ProteinsLgr5 protein, mousePeptidesReceptors, G-Protein-Coupledspasmolytic polypeptidegastric chief cellLgr5metaplasiastem cell

Identifiers

PMID29345968
PMCPMC6732738
OpenAlexW2782886245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.