ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018
Role of selected polymorphisms in determining muscle fiber composition in Japanese men and women.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Association between the ACTN3 R577X polymorphism and skeletal muscle mass: a systematic review and meta-analysis.Journal of physiological anthropology · 2026Pooled it
- Sex differences in human skeletal muscle fiber types and the influence of age, physical activity, and muscle group: A systematic review and meta-analysis.Physiological reports · 2025Pooled it
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
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- Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults.Journal of clinical medicine · 2022Article
- Genetic profile of sports climbing athletes from three different ethnicities.Biology of sport · 2022Article
- The association ofBiology of sport · 2022Article
- The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.Biochimica et biophysica acta. General subjects · 2022Article
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- Association of muscle fiber composition with health and exercise-related traits in athletes and untrained subjects.Biology of sport · 2021Article
- Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives.Sports (Basel, Switzerland) · 2021Review
- Prediction of muscle fiber composition using multiple repetition testing.Biology of sport · 2021Article
- Transcriptomic analysis of the trade-off between endurance and burst-performance in the frog Xenopus allofraseri.BMC genomics · 2021Article
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17 authors at 11 institutions in 1 country.
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Abstract
Genetic polymorphisms and sex differences are suggested to affect muscle fiber composition; however, no study has investigated the effects of genetic polymorphisms on muscle fiber composition with respect to sex differences. Therefore, the present study examined the effects of genetic polymorphisms on muscle fiber composition with respect to sex differences in the Japanese population. The present study included 211 healthy Japanese individuals (102 men and 109 women). Muscle biopsies were obtained from the vastus lateralis to determine the proportion of myosin heavy chain (MHC) isoforms (MHC-I, MHC-IIa, and MHC-IIx). Moreover, we analyzed polymorphisms in α-actinin-3 gene ( ACTN3; rs1815739 ), angiotensin-converting enzyme gene ( ACE; rs4341 ), hypoxia-inducible factor 1 α gene ( rs11549465 ), vascular endothelial growth factor receptor 2 gene ( rs1870377 ), and angiotensin II receptor, type 2 gene ( rs11091046 ), by TaqMan single-nucleotide polymorphism genotyping assays. The proportion of MHC-I was 9.8% lower in men than in women, whereas the proportion of MHC-IIa and MHC-IIx was higher in men than in women (5.0 and 4.6%, respectively). Men with the ACTN3 RR + RX genotype had a 4.8% higher proportion of MHC-IIx than those with the ACTN3 XX genotype. Moreover, men with the ACE ID + DD genotype had a 4.7% higher proportion of MHC-I than those with the ACE II genotype. Furthermore, a combined genotype of ACTN3 R577X and ACE insertion/deletion (I/D) was significantly correlated with the proportion of MHC-I ( r = -0.23) and MHC-IIx ( r = 0.27) in men. In contrast, no significant correlation was observed between the examined polymorphisms and muscle fiber composition in women. These results suggest that the ACTN3 R577X and ACE I/D polymorphisms independently affect the proportion of human skeletal muscle fibers MHC-I and MHC-IIx in men but not in women. NEW & NOTEWORTHY In men, the RR + RX genotype of the α-actinin-3 gene ( ACTN3) R577X polymorphism was associated with a higher proportion of myosin heavy chain (MHC)-IIx. The ID + DD genotype of the angiotensin-converting enzyme gene ( ACE) insertion/deletion (I/D) polymorphism, in contrast to a previous finding, was associated with a higher proportion of MHC-I in men. In addition, the combined genotype of these polymorphisms was correlated with the proportion of MHC-I and MHC-IIx in men. Thus ACTN3 R577X and ACE I/D polymorphisms influence the muscle fiber composition in Japanese men.
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