ArticleOxford medical case reports2018
Clozapine-induced myocarditis.
Article in Oxford medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis.Journal of psychiatry & neuroscience : JPN · 2025Article
- Diagnostic algorithm for clozapine-induced myocarditis: A systematic review.World journal of psychiatry · 2025Article
- Clozapine-induced myocarditis and subsequent rechallenge: a narrative literature review and case report.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2023Article
- Update on Myocarditis: From Etiology and Clinical Picture to Modern Diagnostics and Methods of Treatment.Diagnostics (Basel, Switzerland) · 2023Review
- Myocarditis in patients on long-term antipsychotics -mechanism, management and recent updates.Heliyon · 2023Review
- Clozapine-induced eosinophilia: A case report.SAGE open medical case reports · 2023Article
- Clozapine-Induced Myocarditis in a Young Man with Refractory Schizophrenia: Case Report of a Rare Adverse Event and Review of the Literature.The American journal of case reports · 2022Review
- Article
- "My Heart Said It's Swollen": A Rare Case of Clozapine-Induced Myocarditis in a Schizophrenic Patient.Cureus · 2021Article
- A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance.The American journal of case reports · 2021Article
- Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report.BMC psychiatry · 2020Article
- Clozapine-Induced Cardiotoxicity Presenting as Sepsis: A Case Report and Literature Review.Case reports in medicine · 2019Article
- Clozapine-induced myocarditis in an adolescent male with DiGeorge Syndrome.The mental health clinician · 2018Article
- Iatrogenic myocarditis-biomarkers, cardiovascular MRI and the need for early diagnosis.Oxford medical case reports · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approved in 1989 for the management of treatment-resistant schizophrenia, Clozapine is a last-line atypical antipsychotic drug used with increasing frequency. In addition to its well-known side effect of agranulocytosis, this drug also carries with it rare but serious adverse cardiovascular risk of myocarditis. We present a patient on Clozapine who was admitted to the cardiology service with chest pain, ST segment elevations and elevated troponin concerning for acute myocardial infarction. Evaluation with imaging revealed decreased left ventricular function, however, no coronary artery disease was present on catheterization; findings consistent with a diagnosis of myocarditis. Subsequent discontinuation of the patient's Clozapine and initiation of brief supportive medical therapy resulted in full recovery of systolic left ventricular function. Given the potential cardiovascular mortality risk, it is important for physicians on cardiology services caring for psychiatric patients to be aware of the presentation of symptoms, diagnostic findings and management of Clozapine induced myocarditis.
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