ArticleMicrobial genomics2018
Comparative transcriptomics of Aspergillus fumigatus strains upon exposure to human airway epithelial cells.
Article in Microbial genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen.Nucleic acids research · 2026Article
- The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast.Microbial cell (Graz, Austria) · 2026Article
- Article
- Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems.Microbiology and molecular biology reviews : MMBR · 2024Review
- Accelerating the understanding ofCurrent research in microbial sciences · 2024Review
- Pathogenicity and virulence ofVirulence · 2023Review
- Novel Host Pathways Govern Epithelial Cell Invasion of Aspergillus fumigatus.Microbiology spectrum · 2023Article
- The Transcriptome Response to Azole Compounds inJournal of fungi (Basel, Switzerland) · 2023Article
- In vitro infection models to study fungal-host interactions.FEMS microbiology reviews · 2021Review
- Variation of virulence of five Aspergillus fumigatus isolates in four different infection models.PloS one · 2021Article
- Rapid Detection ofFrontiers in cellular and infection microbiology · 2021Article
- Article
- Molecular Mechanisms of Conidial Germination inMicrobiology and molecular biology reviews : MMBR · 2020Review
- EphA2-Dependent Internalization ofFrontiers in microbiology · 2020Article
- Cost effective, experimentally robust differential-expression analysis for human/mammalian, pathogen and dual-species transcriptomics.Microbial genomics · 2020Article
- Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Expression profile analysis reveals that Aspergillus fumigatus but not Aspergillus niger makes type II epithelial lung cells less immunological alert.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Aspergillus fumigatus is an opportunistic, ubiquitous, saprophytic mould that can cause severe allergic responses in atopic individuals as well as life-threatening infections in immunocompromised patients. A critical step in the establishment of infection is the invasion of airway epithelial cells by the inhaled fungi. Understanding how A. fumigatus senses and responds to airway cells is important to understand the pathogenesis of invasive pulmonary aspergillosis. Here, we analysed the transcriptomes of two commonly used clinical isolates, Af293 and CEA10, during infection of the A549 type II pneumocyte cell line in vitro. We focused our RNA-seq analysis on the core set of genes that are present in the genomes of the two strains. Our results suggest that: (a) A. fumigatus does not mount a conserved transcriptional response to airway epithelial cells in our in vitro model and (b) strain background and time spent in the tissue culture media have a greater impact on the transcriptome than the presence of host cells. Our analyses reveal both common and strain-specific transcriptional programmes that allow for the generation of hypotheses about gene function as it pertains to pathogenesis and the significant phenotypic heterogeneity that is observed among A. fumigatus isolates.
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