ArticleMicrobial genomics2018
Transcriptional changes when Myxococcus xanthus preys on Escherichia coli suggest myxobacterial predators are constitutively toxic but regulate their feeding.
Article in Microbial genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 63 citations in OpenAlex.
- Fatty acid metabolism and the oxidative stress response support bacterial predation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Predatory Bacteria in the Treatment of Infectious Diseases and Beyond.Infectious disease reports · 2024Review
- Siderophores and competition for iron govern myxobacterial predation dynamics.The ISME journal · 2024Article
- From predator to protector:Frontiers in microbiology · 2024Article
- Review
- Interactions of DifferentInternational journal of molecular sciences · 2023Article
- Myxobacteria restrain Phytophthora invasion by scavenging thiamine in soybean rhizosphere via outer membrane vesicle-secreted thiaminase I.Nature communications · 2023Article
- The Fate and Functionality of Alien tRNA Fragments in Culturing Medium and Cells ofInternational journal of molecular sciences · 2023Article
- Two reasons to kill: predation and kin discrimination in myxobacteria.Microbiology (Reading, England) · 2023Review
- Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium Sorangium sp.Microbial biotechnology · 2023Article
- Predatory Strategies ofMicroorganisms · 2023Article
- Comparative genomics and transcriptomics insight into myxobacterial metabolism potentials and multiple predatory strategies.Frontiers in microbiology · 2023Article
- Genetic components ofFrontiers in microbiology · 2023Article
- Thiocillin contributes to the ecological fitness ofFrontiers in microbiology · 2023Article
- Transcriptomic response ofFrontiers in microbiology · 2023Article
- Article
- Characterization of Two Novel Predatory Bacteria,Microorganisms · 2022Article
- Unraveling the expression of differentially expressed proteins and enzymatic activity in response to Phytophthora nicotianae across different flue-cured tobacco cultivars.BMC microbiology · 2022Article
- Differential response to prey quorum signals indicates predatory specialization of myxobacteria and ability to predate Pseudomonas aeruginosa.Environmental microbiology · 2022Article
- Complete identity and expression of StfZ, theFrontiers in microbiology · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Predation is a fundamental ecological process, but within most microbial ecosystems the molecular mechanisms of predation remain poorly understood. We investigated transcriptome changes associated with the predation of Escherichia coli by the myxobacterium Myxococcus xanthus using mRNA sequencing. Exposure to pre-killed prey significantly altered expression of 1319 predator genes. However, the transcriptional response to living prey was minimal, with only 12 genes being significantly up-regulated. The genes most induced by prey presence (kdpA and kdpB, members of the kdp regulon) were confirmed by reverse transcriptase quantitative PCR to be regulated by osmotic shock in M. xanthus, suggesting indirect sensing of prey. However, the prey showed extensive transcriptome changes when co-cultured with predator, with 40 % of its genes (1534) showing significant changes in expression. Bacteriolytic M. xanthus culture supernatant and secreted outer membrane vesicles (OMVs) also induced changes in expression of large numbers of prey genes (598 and 461, respectively). Five metabolic pathways were significantly enriched in prey genes up-regulated on exposure to OMVs, supernatant and/or predatory cells, including those for ribosome and lipopolysaccharide production, suggesting that the prey cell wall and protein production are primary targets of the predator's attack. Our data suggest a model of the myxobacterial predatome (genes and proteins associated with predation) in which the predator constitutively produces secretions which disable its prey whilst simultaneously generating a signal that prey is present. That signal then triggers a regulated feeding response in the predator.
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