ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018
Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation.
Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Hyperoxia and pulmonary vascular injury in bronchopulmonary dysplasia: pathogenic mechanisms and emerging therapies-a systematic review.Pediatric research · 2026Pooled it
- Effects of Di(2-ethylhexyl) phthalate (DEHP) and hyperoxia on cardiovascular development in newborn rats.Pediatric research · 2026Article
- Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia.American journal of physiology. Heart and circulatory physiology · 2025Article
- Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity.Scientific reports · 2024Article
- Neonatal Hyperoxia Activates Activating Transcription Factor 4 to Stimulate Folate Metabolism and Alveolar Epithelial Type 2 Cell Proliferation.American journal of respiratory cell and molecular biology · 2022Article
- Low-dose hyperoxia primes airways for fibrosis in mice after influenza A infection.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Effect of sex chromosomes versus hormones in neonatal lung injury.JCI insight · 2021Article
- Neonatal hyperoxia impairs adipogenesis of bone marrow-derived mesenchymal stem cells and fat accumulation in adult mice.Free radical biology & medicine · 2021Article
- Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.JCI insight · 2021Article
- Analyzing differentially expressed genes and pathways of Bex2-deficient mouse lung via RNA-Seq.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice.Frontiers in immunology · 2021Article
- Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice.Scientific reports · 2020Article
- Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice.bioRxiv : the preprint server for biology · 2020Article
- Pulmonary mechanics and structural lung development after neonatal hyperoxia in mice.Pediatric research · 2020Article
- Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart.American journal of physiology. Heart and circulatory physiology · 2019Article
- Swapping mitochondria: a key to understanding susceptibility to neonatal chronic lung disease.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Rodent models of respiratory control and respiratory system development-Clinical significance.Respiratory physiology & neurobiology · 2019Review
- MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting.Antioxidants (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Supplemental oxygen given to preterm infants has been associated with permanently altering postnatal lung development. Now that these individuals are reaching adulthood, there is growing concern that early life oxygen exposure may also promote cardiovascular disease through poorly understood mechanisms. We previously reported that adult mice exposed to 100% oxygen between postnatal days 0 and 4 develop pulmonary hypertension, defined pathologically by capillary rarefaction, dilation of arterioles and veins, cardiac failure, and a reduced lifespan. Here, Affymetrix Gene Arrays are used to identify early transcriptional changes that take place in the lung before pulmonary capillary rarefaction. We discovered neonatal hyperoxia reduced expression of cardiac muscle genes, including those involved in contraction, calcium signaling, mitochondrial respiration, and vasodilation. Quantitative RT-PCR, immunohistochemistry, and genetic lineage mapping using Myh6
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.