Evidence map›Paper›PMID 29345112›Full record

Trial reportESC heart failure2018

Low NT-proBNP levels in overweight and obese patients do not rule out a diagnosis of heart failure with preserved ejection fraction.

Leo F Buckley, Justin M Canada, Marco G Del Buono, Salvatore Carbone, Cory R Trankle, Hayley Billingsley, Dinesh Kadariya, Ross Arena, Benjamin W Van Tassell, Antonio Abbate

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in ESC heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06101693 (Biomarkers in Patients With Suspected Heart Failure With Preserved Ejection Fraction), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06101693 recruitingnot on this mapstarted 2023, after this paper: background citation

Biomarkers in Patients With Suspected Heart Failure With Preserved Ejection Fraction

TypeobservationalSponsorNHS Greater Glasgow and ClydeRan2023 to 2026Enrolled1,028ConditionsHeart Failure, Obesity, Heart Failure With Preserved Ejection FractionArmsPlasma biomarker levels
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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  20. Effect of body mass index on N-terminal pro-brain natriuretic peptide values in patients with heart failure.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Leo F BuckleyDepartment of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA.
Justin M CanadaVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Marco G Del BuonoVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Salvatore CarboneVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Cory R TrankleVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Hayley BillingsleyVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Dinesh KadariyaVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Ross ArenaDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Benjamin W Van TassellDepartment of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA.
Antonio AbbateVCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad Street, 5th Floor Rm 520, Richmond, VA, 23298, USA.
Virginia Commonwealth University · USSapienza University of Rome · ITUniversity of Illinois Chicago · US

Funding

Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Interleukin-1 blockade in recently decompensated heart failureR34HL117026 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI ABBATE, ANTONIO, VAN TASSELL, BENJAMIN W · 2013 to 2014
$671k
NCATS NIH HHS UL1 TR000058NHLBI NIH HHS R34 HL117026
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that presents clinicians with a diagnostic challenge. The use of natriuretic peptides to exclude a diagnosis of HFpEF has been proposed. We sought to compare HFpEF patients with N-terminal pro-brain natriuretic peptide (NT-proBNP) level above and below the proposed cut-off.

methodsStable patients (n = 30) with left ventricular (LV) ejection fraction ≥ 50% were eligible if they had a diagnosis of HF according to the European Society of Cardiology diagnostic criteria. Characteristics of patients with NT-proBNP below (≤125 pg/mL) and above (>125 pg/mL) the diagnostic criterion were compared.

resultsThere were 19 (66%) women with median age 54 years. Half were African American (16, 53%), and most were obese. There were no significant differences in clinical characteristics or medication use between groups. LV end-diastolic volume index was greater in high NT-proBNP patients (P = 0.03). Left atrial volume index, E/e' ratio, and E/e' ratio at peak exercise were not significantly different between NT-proBNP groups. Peak oxygen consumption (VO

conclusionsNT-proBNP was below the proposed diagnostic cut-off point of 125 pg/mL in half of this obese study cohort. Cardiac diastolic dysfunction and cardiorespiratory fitness were not significantly different between high and low NT-proBNP patients. These data indicate that excluding the diagnosis of HFpEF based solely on NT-proBNP levels should be discouraged.

Indexed as

AgedBiomarkersEchocardiography, DopplerFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedNatriuretic Peptide, BrainObesityOverweightPeptide FragmentsPrognosisProspective StudiesProtein PrecursorsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Protein PrecursorsCardiorespiratory fitnessHeart failure with preserved ejection fractionNatriuretic peptides

Identifiers

PMID29345112
PMCPMC5880665
OpenAlexW2790622599

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.