Evidence map›Paper›PMID 29344809›Full record

ArticleProtein & cell2018

Regeneration of functional alveoli by adult human SOX9

Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang and 1 more

2 registry-linked trialsOpen access · diamondAbstract read
In one paragraph

Article in Protein & cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03655795 phase1unknown statusnot on this map

Autologous Transplantation of Bronchial Basal Cells for Treatment of Chronic Obstructive Pulmonary Disease (COPD)

TypeinterventionalSponsorRuijin HospitalRan2018 to 2021Enrolled20ConditionsCOPDArmsBronchial basal cells
NCT03655808 phase1 / phase2completednot on this mapstarted 2020, after this paper: background citation

Autologous Transplantation of Bronchial Basal Cells for Treatment of Bronchiectasis

TypeinterventionalSponsorRuijin HospitalRan2020 to 2023Enrolled37ConditionsBronchiectasisArmsBronchial basal cells (BBCs), Bronchoscopic airway clearance treatment (B-ACT)
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Autologous transplantation of P63Cell reports. Medicine · 2024
    Trial
  3. Separation of Human P63Analytical chemistry · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Advancements in lung regeneration: from bench to bedside.Journal of translational medicine · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Silicosis: from pathogenesis to therapeutics.Frontiers in pharmacology · 2025
    Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Qiwang MaShanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.
Yu MaShanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.
Xiaotian DaiSouthwest Hospital, Third Military Medical University of PLA, Chongqing, 400038, China.
Tao RenShanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Yingjie FuThe Institute for Biomedical Engineering and Nano Science, School of Medicine, Tongji University, Shanghai, 200029, China.
Wenbin LiuShanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.
Yufei HanShanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.
Yingchuan WuShanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.
Yu ChengThe Institute for Biomedical Engineering and Nano Science, School of Medicine, Tongji University, Shanghai, 200029, China.
Ting ZhangKiangnan Stem Cell Institute, Zhejiang, 311300, China.
Wei ZuoShanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China. zuow@tongji.edu.cn.
Tongji University · CNShanghai Pulmonary Hospital · CNArmy Medical University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9

Indexed as

BronchiectasisHumansPulmonary AlveoliSOX9 Transcription FactorStem CellsStem Cell TransplantationSOX9 Transcription Factoralveolibronchiectasislungregenerationstem celltransplantation

Identifiers

PMID29344809
PMCPMC5829276
OpenAlexW2787511842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.