Evidence map›Paper›PMID 29344692›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study.

N C Wright, E R Hooker, C M Nielson, K E Ensrud, S L Harrison, E S Orwoll, E Barrett-Connor, Osteoporotic Fractures in Men (MrOS) Study Research Group

Abstract readMulticenter Study
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  4. Article
  5. Article
  6. New Challenges: Use and Interpretation of Radius Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2024
    Review
  7. Article
  8. Article
  9. The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Innovative Biomaterials for Bone Regrowth.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

N C WrightDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
E R HookerOHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.
C M NielsonOHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.
K E EnsrudDivision of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, USA.
S L HarrisonSan Francisco Coordinating Center, University of California, San Francisco, San Francisco, CA, USA.
E S OrwollDivision of Endocrinology, Oregon Health & Science University, Portland, OR, USA.
E Barrett-ConnorDivision of Epidemiology, Department of Family Medicine and Public Health, University of San Diego School of Medicine, La Jolla, CA, USA. ebarrettconnor@ucsd.edu.
Osteoporotic Fractures in Men (MrOS) Study Research Group
Oregon Health & Science University · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Minnesota · USUniversity of San Diego · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Osteoporotic Fractures in Men: MrOS Renewal-PortlandU01AR045647 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 1999 to 2011
$6.7M
STUDY OF RISK FACTORS FOR OSTEOPOROSIS IN THE ELDERLYR37AG007181 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1987 to 2010
$5.4M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
UAB K12 in Patient Centered Outcomes ResearchK12HS023009 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2014 to 2018
$4.0M
Osteoporotic Fractures in MenU01AR045583 · NIAMS · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 1999 to 2011
$4.0M
Osteoporotic Fractures in Men - MrOS RenewalU01AR045580 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1999 to 2011
$3.9M
Osteoporotic Fractures in Men- MrOS Renewal - BirminghamU01AR045632 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 1999 to 2011
$3.6M
Osteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0M
AHRQ HHS K12 HS023009NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NIAMS NIH HHS K01 AR062655NIAMS NIH HHS U01 AR045580NIAMS NIH HHS U01 AR045583NIAMS NIH HHS U01 AR045632NIAMS NIH HHS U01 AR045647NIAMS NIH HHS U01 AR066160NIA NIH HHS R01 AG007181NIA NIH HHS R01 AG028507NIA NIH HHS R37 AG007181NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIDDK NIH HHS R01 DK031801
6 · The paper itself

Abstract

There is limited wrist fracture information on men. Our goal was to calculate frequency and identify risk factors for wrist fracture in the Osteoporotic Fractures in Men (MrOS) study. We confirmed that fracture history and certain medications are predictors, and identified novel predictors including markers of kidney function and physical performance.

introductionTo calculate the incidence of wrist fractures and their risk factors in older community-dwelling men from the US Osteoporotic Fractures in Men (MrOS) study.

methodsUsing triannual postcards, we identified incident wrist fractures (centrally confirmed by radiology) in men aged ≥ 65. Potential risk factors included the following: demographics, lifestyle, bone mineral density (BMD), selected medications, biomarkers, and physical function and performance measures. Both baseline and time-varying models were adjusted for age, race/ethnicity, MrOS geographic location, and competing mortality risks.

resultsWe observed 97 incident wrist fractures among 5875 men followed for an average of 10.8 years. The incidence of wrist fracture was 1.6 per 1000 person-years overall and ranged from 1.0 among men aged 65-69 to 2.4 among men age ≥ 80. Significant predictors included the following: fracture history after age 50 [hazard ratio (95% CI): 2.48 (1.65, 3.73)], high serum phosphate [1.25 (1.02, 1.53)], use of selective serotonin receptor inhibitor (SSRI) [3.60 (1.96, 6.63), decreased right arm BMD [0.49 (0.37, 0.65) per SD increase], and inability to perform the grip strength test [3.38 (1.24, 9.25)]. We did not find associations with factors commonly associated with wrist and other osteoporosis fractures like falls, diabetes, calcium and vitamin D intake, and alcohol intake.

conclusionsAmong these older, community-dwelling men, we confirmed that fracture history is a strong predictor of wrist fractures in men. Medications such as SSRIs and corticosteroids also play a role in wrist fracture risk. We identified novel risk factors including kidney function and the inability to perform the grip strength test.

Indexed as

Accidental FallsAgedAged, 80 and overAge DistributionAge FactorsHumansIncidenceIndependent LivingMaleOsteoporotic FracturesPhysical Functional PerformanceProspective StudiesRecurrenceRisk FactorsUnited StatesWrist InjuriesEpidemiologyMenRisk factorsWrist fracture

Identifiers

PMID29344692
PMCPMC5939930
OpenAlexW2784450563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.