ArticleJAMA cardiology2018
Association of Depression With Mortality in Older Adults Undergoing Transcatheter or Surgical Aortic Valve Replacement.
Article in JAMA cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03995914 (Impact of Depression on 1-year Major Adverse Events in Patients Aged 75 or Older Who Undergo Transcatheter Aortic Valve Implantation), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Depression on 1-year Major Adverse Events in Patients Aged 75 or Older Who Undergo Transcatheter Aortic Valve Implantation (TAVIDEP)
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and course of depression in older people with aortic stenosis undergoing transcatheter aortic valve implantation - a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies.Molecular psychiatry · 2023Pooled it
- Self-Reported Quality of Life and 30-Day Mortality in Elective Cardiac Surgery.JACC. Advances · 2026Article
- Impact of depression on TAVR wait time and post-TAVR outcomes: a population-based study.European heart journal open · 2026Article
- Indicators of mortality risk in ageing horses.GeroScience · 2025Article
- The relationship between depression and cardiovascular disease in older people: results from a large-scale epidemiological cohort study in Japan.European geriatric medicine · 2025Article
- Understanding patients' emotional needs to strengthen therapeutic relationships: A deep insight into narrative nursing.World journal of psychiatry · 2025Article
- Article
- Clinical Benefits and Challenges of Esketamine in Elderly Patients During the Perioperative Period.Drug design, development and therapy · 2025Review
- Depression in Patients With Symptomatic Aortic Stenosis Predicts 3-Year Mortality After Transcatheter Aortic Valve Implantation.JACC. Advances · 2024Article
- Vestibular schwannoma surgery in the ninth decade of life: a case series.Acta neurochirurgica · 2024Observational
- The Association between Aortic Valve Stenosis and a Subsequent Diagnosis of Depression in Germany.Journal of clinical medicine · 2024Article
- Depression and Malnutrition for Prediction of Mortality after Transcatheter Aortic Valve Replacement: A Registry Study of a Tertiary Referral Hospital.Diagnostics (Basel, Switzerland) · 2023Article
- Quality of Life and Depressive Symptoms in Transcatheter Aortic Valve Implementation Patients-A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2022Article
- Hospital nursing factors associated with decreased odds of mortality in older adult medicare surgical patients with depression.BMC geriatrics · 2022Article
- Comparison of the levels of depression and anxiety in elderly aortic stenosis patients treated with surgical or transcatheter aortic valve replacement.Journal of cardiothoracic surgery · 2022Article
- Anxiety and Depression Following Aortic Valve Replacement.Journal of the American Heart Association · 2022Article
- Surgical aortic valve replacement in elderly patients: effects on physical performance, cognitive function and health-related quality of life.Aging clinical and experimental research · 2022Article
- [Depressive symptoms and mortality in older people in Latin America: systematic review and meta-analysisSíntomas de depresión y mortalidad en personas mayores en América Latina: revisión sistemática con metanálisis].Revista panamericana de salud publica = Pan American journal of public health · 2022Review
- Twelve-Month Cognitive and Functional Outcomes Following Cardiac Surgery: The DEXACET Trial of Intravenous Acetaminophen Versus Placebo.Frontiers in pharmacology · 2022Article
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Authors and funding
23 authors.
Funding
Abstract
Importance: Depression is increasingly recognized as a risk factor for adverse outcomes in cardiovascular disease. However, little is known about depression in older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement. Objective: To determine the prevalence of depression and its association with all-cause mortality in older adults undergoing TAVR or SAVR. Design, Setting, and Participants: This preplanned analysis of the Frailty Aortic Valve Replacement (FRAILTY-AVR) prospective cohort study included 14 centers in 3 countries from November 15, 2011, through April 7, 2016. Individuals 70 years or older who underwent TAVR or SAVR were enrolled. Depressive symptoms were evaluated using the Geriatric Depression Scale Short Form at baseline and follow-up. Main Outcomes and Measures: All-cause mortality at 1 and 12 months after TAVR or SAVR. Logistic regression was used to determine the association of depression with mortality after adjusting for confounders such as frailty and cognitive impairment. Results: Among 1035 older adults (427 men [41.3%] and 608 women [58.7%]) with a mean (SD) age of 81.4 (6.1) years, 326 (31.5%) had a positive result of screening for depression, whereas only 89 (8.6%) had depression documented in their clinical record. After adjusting for clinical and geriatric confounders, baseline depression was found to be associated with mortality at 1 month (odds ratio [OR], 2.20; 95% CI, 1.18-4.10) and at 12 months (OR, 1.532; 95% CI, 1.03-2.24). Persistent depression, defined as baseline depression that was still present 6 months after the procedure, was associated with a 3-fold increase in mortality at 12 months (OR, 2.98; 95% CI, 1.08-8.20). Conclusions and Relevance: One in 3 older adults undergoing TAVR or SAVR had depressive symptoms at baseline and a higher risk of short-term and midterm mortality. Patients with persistent depressive symptoms at follow-up had the highest risk of mortality.
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