ArticleKidney diseases (Basel, Switzerland)2017
MicroRNAs in Renal Diseases: A Potential Novel Therapeutic Target.
Article in Kidney diseases (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The Role of MicroRNA in Contrast-Induced Nephropathy: A Scoping Review and Meta-Analysis.BioMed research international · 2020Pooled it
- MiR-29b modulates DNA methylation in promoter region of miR-130b in mouse model of Diabetic nephropathy.Journal of diabetes and metabolic disorders · 2023Article
- Effects of Exosomes Derived from Kidney Tubular Cells on Diabetic Nephropathy in Rats.Cell journal · 2022Article
- lncRNA MALAT1 Promotes Diabetic Nephropathy Progression via miR-15b-5p/TLR4 Signaling Axis.Journal of immunology research · 2022Article
- Fatty Acid β-Oxidation in Kidney Diseases: Perspectives on Pathophysiological Mechanisms and Therapeutic Opportunities.Frontiers in pharmacology · 2022Review
- The program of renal fibrogenesis is controlled by microRNAs regulating oxidative metabolism.Redox biology · 2021Article
- Oligonucleotide-Based Therapies for Renal Diseases.Biomedicines · 2021Review
- LncRNA MALAT1 promoted high glucose-induced pyroptosis of renal tubular epithelial cell by sponging miR-30c targeting for NLRP3.The Kaohsiung journal of medical sciences · 2020Article
- Modeling epigenetic modifications in renal development and disease with organoids and genome editing.Disease models & mechanisms · 2018Review
- Neutrophil Elastase Inhibitors and Chronic Kidney Disease.International journal of biological sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) are a family of short noncoding RNAs that play important roles in posttranscriptional gene regulation. miRNAs inhibit target gene expression by blocking protein translation or by inducing mRNA degradation and therefore have the potential to modulate physiological and pathological processes. SUMMARY: In the kidney, miRNAs play a role in the organogenesis and in the pathogenesis of several diseases, including renal carcinoma, diabetic nephropathy, cystogenesis, and glomerulopathies. Indeed, podocytes, but also the parietal cells of the Bowman capsule are severely affected by miRNA deregulation. In addition, several miRNAs have been found involved in the development of renal fibrosis. These experimental lines of evidence found a counterpart also in patients affected by diabetic and Ig-A nephropathies, opening the possibility of their use as biomarkers. Finally, the possibility to direct target-specific miRNA to prevent the development of renal fibrosis is encouraging potential novel therapies based on miRNA mimicking or antagonism. This review reports the main studies that investigate the role of miRNAs in the kidneys, in particular highlighting the experimental models used, their potential role as biomarkers and, finally, the most recent data on the miRNA-based therapy. KEY MESSAGES: miRNAs are crucial regulators of cell function. They are easy to detect and represent potentially good targets for novel therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.