ArticleOcular oncology and pathology2017
A Case of Adenocarcinoma of the Retinal Pigment Epithelium: An Immunohistochemical and Electron Microscopic Study.
Article in Ocular oncology and pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- [Retinal tumors in adults: Part 2 nonvascular tumors of retina and retinal pigment epithelium].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- Retinal Pigment Epithelium Adenoma and Adenocarcinoma: A Review.Ocular oncology and pathology · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRetinal pigment epithelium (RPE) adenocarcinoma is a very rare malignant intraocular tumor. Herein we describe the histopathological features of RPE adenocarcinoma. CASE: A 36-year-old male was referred to our clinic because of floaters in his left eye. The initial diagnosis was malignant melanoma of the choroid. We resected the tumor and studied it histopathologically. The tumor tissue was investigated by light microscopy including immunohistochemistry using antibodies against S-100, HMB-45, EMA, and AE-1. Electron microscopic examination was also performed.
resultsThe tumor arose from the RPE and contained intracytoplasmic vacuoles and abundant melanin pigment. There were no nevoid cells in the choroid. A small part of the tumor cells showed tubular or lobular proliferation and choroidal invasion. Immunohistochemistry revealed positive staining in tumor cells with 4 antibodies. Tight cellular junctions specific to the RPE were confirmed by electron microscopy. The final diagnosis was RPE adenocarcinoma.
conclusionsMost pigmented intraocular tumors are nevus and malignant melanomas of the choroid. It is easy to misdiagnose a RPE adenocarcinoma as a malignant melanoma of the choroid. An exact differential diagnosis should be determined by immunohistopathological and electron microscopic examination.
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