Evidence map›Paper›PMID 29344483›Full record

ArticleOcular oncology and pathology2017

Retinoinvasive Uveal Melanoma: Report of 2 Cases and Review of the Literature.

John P Gorham, Eszter Szalai, Jill R Wells, Hans E Grossniklaus

Open access · bronzeAbstract read
In one paragraph

Article in Ocular oncology and pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

John P GorhamDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Eszter SzalaiDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Jill R WellsDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Hans E GrossniklausDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Emory University · USOphthalmology Associates (United States) · US

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H · 1986 to 2025
$15.3M
NEI NIH HHS P30 EY006360
6 · The paper itself

Abstract

purposeTo describe the clinical history and histopathologic findings of 2 cases of retinoinvasive uveal melanoma.

methodsThe medical records and pathology specimens of 2 patients with retinoinvasive uveal melanoma were reviewed.

resultsThe first patient had an iris/ciliary body melanoma that was treated and the second patient had suspected iridocorneal endothelial syndrome. Both patients developed a blind, painful eye; the first patient's right eye was enucleated and the left eye of the second patient underwent evisceration. Histopathologic examination of the enucleated eye showed a tumor composed of minimally pigmented spindle-shaped cells with fusiform nuclei and prominent nucleoli and round cells with prominent nucleoli. The tumor cells invaded into the retina where they formed perivascular aggregates. Examination of the evisceration specimen showed a proliferation of pigmented tumor cells within the stroma of one iris leaflet. The tumor cells extended onto the ciliary body and vitreous base and invaded the retina. The pathologic diagnosis in both patients was retinoinvasive uveal melanoma.

conclusionsCareful funduscopic and imaging examination should be performed in eyes with unilateral glaucoma with iris/ciliary body lesions, and enucleation, rather than evisceration, should be performed, as retinoinvasive melanoma is in the differential diagnosis.

Indexed as

Choroidal melanomaOcular cancerRetinoinvasive melanoma

Identifiers

PMID29344483
PMCPMC5757583
OpenAlexW2605972696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.