ArticleOcular oncology and pathology2017
Mechanisms of Optic Nerve Invasion in Primary Choroidal Melanoma.
Article in Ocular oncology and pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Insights into shape of uveal melanoma: a comprehensive evaluation of clinical features, pathological features, and prognosis analysis.Frontiers in medicine · 2025Article
- Optic nerve invasion of non-juxtapapillary uveal melanoma: a rare occurrence.BMJ case reports · 2020Article
- Optic disc and peripapillary tumors.Taiwan journal of ophthalmologyReview
- Beyond the Eye: A Unique Case of Choroidal Melanoma with Extra-Ocular Extension.Case reports in oncologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimThe aim of this study was to assess morphological risk factors associated with optic nerve invasion of choroidal melanoma and to identify possible mechanisms of optic nerve invasion.
methodsMedical charts and histology slides of patients with primary choroidal melanoma who were treated by enucleation/exenteration and whose pathology showed optic nerve invasion were reviewed.
resultsTwenty-one patients (mean age: 65.67 ± 14.72 years) with primary uveal melanoma arising from the choroid were included in this analysis. A peripapillary location was present in 86% of the cases. Four types of optic nerve invasion were identified: transvitreal invasion (10%); retinal invasion (23%); direct peripapillary invasion (57%); and a combined mechanism (10%). Optic nerve invasion was prelaminar in 67%, laminar in 10%, and retrolaminar in 23% of the cases. Significantly higher largest basal diameter (
conclusionsA peripapillary tumor location was the most common mechanism of optic nerve invasion of choroidal melanoma. In 43% of the cases, other mechanisms including transvitreal and retinal invasion resulted in optic nerve invasion.
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