ArticleAging and disease2017
Age-Related Gray and White Matter Changes in Normal Adult Brains.
Article in Aging and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The effect of repetitive transcranial magnetic stimulation on immediate and long-term cognitive functions in Alzheimer's dementia and mild cognitive impairment: a meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- No reliable gray matter alterations in idiopathic dystonia.Frontiers in neurology · 2025Pooled it
- Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2022Pooled it
- White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- When Music Loses Its Pleasure: Hippocampal Cingulum White Matter as a Structural Mediator of Musical Reward Decline in Aging.bioRxiv : the preprint server for biology · 2026Article
- A comparative assessment of age- and gender-related variations in brain morphometry using linear and volumetric MRI analysis.BMC medical imaging · 2026Article
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- First establishment of population-specific brain volume reference standards for Chinese children and adolescents: an AI-based segmentation study.Frontiers in pediatrics · 2025Article
- Regional network covariance patterns of white matter integrity related to cardiorespiratory fitness in healthy aging.Frontiers in aging neuroscience · 2025Article
- Low-Rank Tensor Fusion for Enhanced Deep Learning-Based Multimodal Brain Age Estimation.Brain sciences · 2024Article
- The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives.Aging and disease · 2024Review
- High Blood Pressure and Impaired Brain Health: Investigating the Neuroprotective Potential of Magnesium.International journal of molecular sciences · 2024Review
- Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study.Age and ageing · 2024Article
- A computer approach to assess age-related changes of the brain white matter in Alzheimer's disease.Heliyon · 2024Article
- Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Evaluating age-and gender-related changes in brain volumes in normal adult using synthetic magnetic resonance imaging.Brain and behavior · 2024Article
- Aging, cingulate cortex, and cognition: insights from structural MRI, emotional recognition, and theory of mind.Brain structure & function · 2024Article
- The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [European journal of nuclear medicine and molecular imaging · 2024Article
- Acquisition-invariant brain MRI segmentation with informative uncertainties.Medical image analysis · 2024Article
- Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA).Cerebral circulation - cognition and behavior · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal aging is associated with both structural changes in many brain regions and functional declines in several cognitive domains with advancing age. Advanced neuroimaging techniques enable explorative analyses of structural alterations that can be used as assessments of such age-related changes. Here we used voxel-based morphometry (VBM) to investigate regional and global brain volume differences among four groups of healthy adults from the IXI Dataset: older females (OF, mean age 68.35 yrs; n=69), older males (OM, 68.43 yrs; n=66), young females (YF, 27.09 yrs; n=71), and young males (YM, 27.91 yrs; n=71), using 3D T1-weighted MRI data. At the global level, we investigated the influence of age and gender on brain volumes using a two-way analysis of variance. With respect to gender, we used the Pearson correlation to investigate global brain volume alterations due to age in the older and young groups. At the regional level, we used a flexible factorial statistical test to compare the means of gray matter (GM) and white matter (WM) volume alterations among the four groups. We observed different patterns in both the global and regional GM and WM alterations in the young and older groups with respect to gender. At the global level, we observed significant influences of age and gender on global brain volumes. At the regional level, the older subjects showed a widespread reduction in GM volume in regions of the frontal, insular, and cingulate cortices compared to the young subjects in both genders. Compared to the young subjects, the older subjects showed a widespread WM decline prominently in the thalamic radiations, in addition to increased WM in pericentral and occipital areas. Knowledge of these observed brain volume differences and changes may contribute to the elucidation of mechanisms underlying aging as well as age-related brain atrophy and disease.
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