Evidence map›Paper›PMID 29344345›Full record

ArticleTherapeutic advances in psychopharmacology2018

When the drugs don't work: treatment-resistant schizophrenia, serotonin and serendipity.

Penelope Lowe, Amir Krivoy, Lilla Porffy, Erna Henriksdottir, Whiskey Eromona, Sukhwinder S Shergill

Abstract read
In one paragraph

Article in Therapeutic advances in psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia.International journal of molecular sciences · 2022
    Review
  9. Advantages and Limitations of Animal Schizophrenia Models.International journal of molecular sciences · 2022
    Review
  10. Vortioxetine as adjunctive therapy in the treatment of schizophrenia.Therapeutic advances in psychopharmacology · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Penelope LoweNational Psychosis Service, South London and Maudsley NHS Foundation Trust, UK.
Amir KrivoyPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, 16 De Crespigny Park, London, SE5 8AF, UK.
Lilla PorffyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Erna HenriksdottirNational Psychosis Service, South London and Maudsley NHS Foundation Trust, UK. University of Iceland, Iceland.
Whiskey EromonaNational Psychosis Service, South London and Maudsley NHS Foundation Trust, UK. Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Sukhwinder S ShergillNational Psychosis Service, South London and Maudsley NHS Foundation Trust, UK. Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

Funding

European Research Council 311686Medical Research Council G0901868
6 · The paper itself

Abstract

Treatment-resistant schizophrenia is a serious clinical problem. We adopt a systems-level approach positing a greater role for cognitive control mechanisms in the development of psychotic symptoms and illustrate the clinical application of this

Indexed as

cognitionnovel treatmentrefractory schizophrenia

Identifiers

PMID29344345
PMCPMC5761908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.