Evidence map›Paper›PMID 29344305›Full record

ArticleTheranostics2018

A Tumor-Activatable Theranostic Nanomedicine Platform for NIR Fluorescence-Guided Surgery and Combinatorial Phototherapy.

Xiaoning Li, Canan Schumann, Hassan A Albarqi, Christopher J Lee, Adam W G Alani, Shay Bracha, Milan Milovancev, Olena Taratula, Oleh Taratula

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Review
  3. Optical and Photoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  4. Article
  5. Review
  6. Lysosome-Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting.International journal of molecular sciences · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. A targeted combinatorial therapy for Ewing's sarcoma.Nanomedicine : nanotechnology, biology, and medicine · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaoning LiDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Canan SchumannDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Hassan A AlbarqiDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Christopher J LeeDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Adam W G AlaniDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Shay BrachaDepartment of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, United States.
Milan MilovancevDepartment of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, United States.
Olena TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Oleh TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR 97201, United States.
Oregon State University · US

Funding

Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
Combinatorial Nanotherapeutic Approach for Advanced Prostate Cancer TreatmentR15EB020351 · NIBIB · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2016 to 2016
$441k
NCATS NIH HHS KL2 TR002370NIBIB NIH HHS R15 EB020351
6 · The paper itself

Abstract

Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy.

Indexed as

AnimalsFemaleFluorescent DyesHEK293 CellsHumansLactonesMiceMice, NudeNanoparticlesNeoplasms, ExperimentalPhototherapyPolyethylene GlycolsPorphyrinsSpectroscopy, Near-InfraredSurgery, Computer-AssistedTheranostic Nanomedicine2,3-naphthalocyanineFluorescent DyesLactonespoly(ethylene glycol)-block-poly(epsilon-caprolactone)Polyethylene GlycolsPorphyrinsactivatableNIR theranosticovarian cancer.PEG-PCLsilicon naphthalocyanine

Identifiers

PMID29344305
PMCPMC5771092
OpenAlexW2771293733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.