ArticleOncology letters2017
miR-203a suppresses cell proliferation by targeting E2F transcription factor 3 in human gastric cancer.
Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Biomarker potential of competing endogenous RNA networks in Polycystic Ovary Syndrome (PCOS).Non-coding RNA research · 2024Review
- eIF4A3-induced circWAC promotes breast cancer progression through mediating miR-599/E2F3 axis.The Kaohsiung journal of medical sciences · 2022Article
- Bioinformatics Prediction and Analysis of MicroRNAs and Their Targets as Biomarkers for Prostate Cancer: A Preliminary Study.Molecular biotechnology · 2022Article
- Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma.Archives of toxicology · 2022Article
- Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3.Digestive diseases and sciences · 2021Article
- Epstein-Barr Virus miR-BART1-3p Regulates the miR-17-92 Cluster by Targeting E2F3.International journal of molecular sciences · 2021Article
- miRNA Profiling of Hungarian Regressive Wilms' Tumor Formalin-Fixed Paraffin-Embedded (FFPE) Samples by Quantitative Real-Time Polymerase Chain Reaction (RT-PCR).Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- MicroRNAs are involved in the development and progression of gastric cancer.Acta pharmacologica Sinica · 2021Review
- E2F1/2/4 mRNA is associated with immune infiltration and are potential biomarkers for the prognosis of human gastric carcinoma.Translational cancer research · 2021Article
- miR-122-5p Mediates Fluoride-Induced Osteoblast Activation by Targeting CDK4.Biological trace element research · 2021Article
- Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein β Axis.Cancer management and research · 2021Article
- Review
- mFrontiers in oncology · 2021Article
- Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer.International journal of medical sciences · 2021Review
- Bioinformatic Analysis Identified Potentially Prognostic Long Noncoding RNAs and MicroRNAs for Gastric Cancer.BioMed research international · 2021Article
- Article
- Novel Potential Therapeutic Target for E2F1 and Prognostic Factors of E2F1/2/3/5/7/8 in Human Gastric Cancer.Molecular therapy. Methods & clinical development · 2020Article
- CircRHOT1 mediated cell proliferation, apoptosis and invasion of pancreatic cancer cells by sponging miR-125a-3p.Journal of cellular and molecular medicine · 2020Article
- MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts.Bioscience reports · 2019Article
- MicroRNA‑3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A.Molecular medicine reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRs) are a class of short non-coding RNAs that serve an essential role in the tumorigenesis of gastric cancer (GC). MiR-203a has been reported as a tumor repressor in various types of human cancer. In the present study, the function of miR-203a on the proliferation of GC cells was investigated. Bioinformatics analyses revealed that miR-203a targets the 3'-untranslated region of E2F transcription factor 3 (E2F3) messenger RNA. A luciferase reporter assay and western blot analysis were performed to confirm whether E2F3 was a target of miR-203a. The relative luciferase activity was decreased when overexpressing miR-203a with E2F3-wild type pmirGLO-3'-untranslated region vector, compared with the control group in HEK293 cells. Overexpression of miR-203a suppressed cell proliferation and colony formation of SGC-7901 and AGS GC cells. Inhibition of miR-203a promoted the proliferation of GC cells. Collectively, the results indicated that miR-203a may function as a tumor suppressor in GC by targeting E2F3.
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