ArticleOncology letters2017
C-reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer.
Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Prognostic role of the pretreatment C-reactive protein/albumin ratio in gastric cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Inflammatory markers for predicting overall survival in gastric cancer patients: A systematic review and meta-analysis.PloS one · 2020Pooled it
- An inflammation-nutrition composite index and its dynamic change for predicting postoperative wound complications.Langenbeck's archives of surgery · 2026Observational
- Article
- The preoperative albumin-to-carcinoembryonic antigen ratio (ACR) predicts prognosis and facilitates risk stratification in gastric cancer: a retrospective cohort study.Frontiers in nutrition · 2026Article
- The evaluation of inflammatory and immune composite markers for complications after deceased donor liver transplantation - a retrospective cohort study.Annals of medicine · 2025Article
- Combined albumin and CEA improve prognostic prediction in resectable gastric cancer.Scientific reports · 2025Article
- CRP to Albumin Ratio as a Prognostic Nutrition-Based Biomarker for Patients With Gastric Cancer: A Narrative Review.Cureus · 2024Review
- Can the Pathological Response in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Treatment Be Predicted by the CEA/Albumin and CRP/Albumin Ratios?Journal of clinical medicine · 2024Article
- The inflammatory prognostic index as a potential predictor of prognosis in metastatic gastric cancer.Scientific reports · 2023Article
- Association between peripheral blood cytopenia and cancer mortality: A race-specific risk factor for cancer death.Cancer medicine · 2023Observational
- C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis.Mediterranean journal of rheumatology · 2023Article
- Interleukin-6-to-Albumin Ratio as a Superior Predictor of Mortality in End-Stage Kidney Disease Patients.American journal of nephrology · 2023Article
- Neutrophil-to-lymphocyte ratio and C-reactive protein-to-albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer.Langenbeck's archives of surgery · 2022Article
- Association of inflammatory markers with survival in patients with advanced gastric cancer treated with immune checkpoint inhibitors combined with chemotherapy as first line treatment.Frontiers in oncology · 2022Article
- Cross sectional association between cytomegalovirus seropositivity, inflammation and cognitive impairment in elderly cancer survivors.Cancer causes & control : CCC · 2022Article
- Clinical significance and prognostic value of C-reactive protein/albumin ratio in gastric cancer.Annals of surgical treatment and research · 2021Article
- Serum C-reactive protein to albumin ratio and mortality associated with peritoneal dialysis.Renal failure · 2020Article
- Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer.World journal of gastrointestinal oncology · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple studies have reported the prognostic association of certain inflammatory factors with various types of cancer. The present study assessed the prognostic value of the C-reactive protein (CRP)/albumin (Alb) ratio and the neutrophil/lymphocyte ratio (NLR), separately and in combination, in gastric cancer (GC). A total of 337 cases pathologically diagnosed with gastric adenocarcinoma were retrospectively evaluated. The clinicopathological and prognostic relevance of the CRP/Alb ratio and NLR and their combination were analyzed. The optimal cut-off values of the CRP/Alb ratio and NLR were 0.38 and 3.14, respectively. High CRP/Alb ratio (≥0.38) and NLR (≥3.14) values were associated with increased tumor invasion, more distant metastasis and a more advanced tumor-node-metastasis stage (all P<0.05). In addition, a high NLR value was also associated with increased tumor size (P=0.02). The CRP/Alb ratio (≥0.38/<0.38) and NLR (≥3.14/<3.14) were independent prognostic factors for overall survival time (OS) in GC by multivariate analysis (P=0.005 and P=0.001). Using the CRP/Alb ratio and NLR classification, patients were stratified into three subgroups with different OS time (P<0.001), which were identified as independent prognostic variables in multivariate analysis (P<0.001). The present study demonstrated that the CRP/Alb ratio and NLR were independent prognostic factors for OS in patients with GC. The combination of these indexes was associated with significant prognostic value and may further stratify prognosis.
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