Evidence map›Paper›PMID 29344066›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2017

Diagnostic Challenge: Sequential Unilateral Cranial Neuropathies Due to Perineural Spread of Carcinoma.

Heather E Moss, Peter W MacIntosh, Konstantin V Slavin, John M Collins

Abstract read
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Heather E MossDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Peter W MacIntoshDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Konstantin V SlavinDepartment of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA.
John M CollinsDepartment of Radiology, University of Chicago, Chicago, Illinois, USA.
University of Illinois Chicago · USUniversity of Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 1985 to 2025
$14.8M
Physiologically Based Markers of Idiopathic Intracranial HypertensionK23EY024345 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MOSS, HEATHER ELSPETH · 2014 to 2018
$1.1M
NEI NIH HHS K23 EY024345NEI NIH HHS P30 EY001792
6 · The paper itself

Abstract

An 86-year old man developed sequential dysfunction of trigeminal (V1), facial, abducens, trigeminal (v2), oculomotor, and hypoglossal cranial nerves on the right over 20 months. Magnetic resonance imaging (MRI) showed a lesion in the right cavernous sinus. Although there was clinical suspicion that this was related to perineural spread of an extracranial tumour, a primary lesion was not discovered. Stereotactic biopsies of the intracranial lesion were non-diagnostic, and the patient succumbed to his tumour following a period of rapid growth. Postmortem examination showed the intracranial lesion to be a carcinoma with squamous features. This case highlights the challenges of diagnosis of intracranial perineural spread and the potential for transformation from indolent to aggressive tumour behaviour.

Indexed as

Carcinomacranial neuropathiesperineural spread

Identifiers

PMID29344066
PMCPMC5762146
OpenAlexW2608507998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.