ArticleCardiorenal medicine2017
Evaluation of the Predictive Value of the Serum Calcium-Magnesium Ratio for All-Cause and Cardiovascular Mortality in Incident Dialysis Patients.
Article in Cardiorenal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The dietary calcium-to-magnesium ratio and its association with glycemic control in type 2 diabetes: a cross-sectional study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Review
- Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases.Biological trace element research · 2025Article
- Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases.Biological trace element research · 2025Article
- Associations of calcium and magnesium intakes and their intake ratio with albuminuria in middle-aged and older adults.PloS one · 2025Article
- Relationship between calcium-to-magnesium ratio and malaria parasite density among children with uncomplicated malaria infection.African health sciences · 2024Article
- Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2024Article
- The association between serum magnesium and chronic kidney disease in Chinese adults: a cross-sectional study.BMC public health · 2024Article
- Lower serum magnesium is a predictor of left ventricular hypertrophy in patients on dialysis.International urology and nephrology · 2023Article
- Mineral micronutrient status and spatial distribution among the Ethiopian population.The British journal of nutrition · 2022Article
- The Usefulness of Calcium/Magnesium Ratio in the Risk Stratification of Early Onset of Renal Replacement Therapy.Diagnostics (Basel, Switzerland) · 2022Article
- Pre-diagnostic dietary consumption of calcium and magnesium and calcium-to-magnesium intake ratio and ovarian cancer mortality: results from the ovarian cancer follow-up study (OOPS).European journal of nutrition · 2022Article
- Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases.Nutrients · 2022Article
- Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients.Nutrients · 2022Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimCardiovascular disease is the most serious cause of death in patients on hemodialysis. Low serum magnesium (Mg) and high serum calcium (Ca) levels have been associated with poor outcome and cardiovascular mortality in patients on maintenance and initiation dialysis. As a more accurate marker is warranted, we evaluated the efficacy of a novel serum Ca-Mg marker of all-cause and cardiovascular mortality that indicates vessel calcification.
methodsWe recruited 378 consecutive patients with end-stage renal disease who started dialysis between January 2009 and December 2015 at the Japanese Red Cross Ishinomaki Hospital. We collected data of patients' demographic characteristics and comorbidities from their electronic medical records. We retrospectively examined the association of the serum Ca-Mg ratio with all-cause and cardiovascular mortality using the Cox proportional hazard model, and determined the value that predicted cardiovascular death using the receiver operating characteristic (ROC) curve.
resultsOverall, 253 patients with serum Mg and Ca data were analyzed. The 3-year survival rate of this group was 0.70 (95% confidence interval [CI] 0.55-0.80), and the hazard ratio for the risk of death was 3.94 (95% CI 1.37-11.31). The 3-year cardiovascular mortality rate was 0.12 (95% CI 0.05-0.23), which was significantly higher than that of the other groups. The ROC curve of cardiovascular mortality with the Ca-Mg ratio was greater than that of Mg (area under the curve 0.75 vs. 0.69,
conclusionA high Ca-Mg ratio was significantly associated with all-cause and cardiovascular mortality, and it was more accurate than serum Mg.
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