Evidence map›Paper›PMID 29343956›Full record

ArticleInternational journal of nanomedicine2018

Essential oil-loaded lipid nanoparticles for wound healing.

Francesca Saporito, Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Cinzia Boselli, Antonia Icaro Cornaglia, Barbara Mannucci, Pietro Grisoli, Barbara Vigani, Franca Ferrari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 232 citations in OpenAlex.

  1. Review
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  10. An Update of Phytotherapeutic Advances of Marigold (Plants (Basel, Switzerland) · 2025
    Review
  11. Review
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  13. Review
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  15. Effective Control ofAntibiotics (Basel, Switzerland) · 2025
    Article
  16. Article
  17. Review
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  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Francesca SaporitoDepartment of Drug Sciences, University of Pavia, Pavia.
Giuseppina SandriDepartment of Drug Sciences, University of Pavia, Pavia.
Maria Cristina BonferoniDepartment of Drug Sciences, University of Pavia, Pavia.
Silvia RossiDepartment of Drug Sciences, University of Pavia, Pavia.
Cinzia BoselliDepartment of Drug Sciences, University of Pavia, Pavia.
Antonia Icaro CornagliaDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia.
Barbara MannucciCentro Grandi Strumenti, University of Pavia, Pavia, Italy.
Pietro GrisoliDepartment of Drug Sciences, University of Pavia, Pavia.
Barbara ViganiDepartment of Drug Sciences, University of Pavia, Pavia.
Franca FerrariDepartment of Drug Sciences, University of Pavia, Pavia.
University of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds. Lipid nanoparticles were based on natural lipids: cocoa butter, as solid lipid, and olive oil or sesame oil, as liquid lipids. Lecithin was chosen as surfactant to stabilize nanoparticles and to prevent their aggregation. The systems were prepared by high shear homogenization followed by ultrasound application. Nanoparticles were characterized for physical-chemical properties, bioadhesion, cytocompatibility, in vitro proliferation enhancement, and wound healing properties toward normal human dermal fibroblasts. Antimicrobial activity of nanoparticles was evaluated against two reference microbial strains, one of

Indexed as

AnimalsAnti-Infective AgentsCell ProliferationDrug CarriersEucalyptusFibroblastsHumansLecithinsLipidsMaleNanoparticlesOils, VolatileRatsRats, WistarStaphylococcus aureusStreptococcus pyogenesAnti-Infective AgentsDrug CarriersLecithinsLipidsOils, Volatilerosemary oilantimicrobial propertieseucalyptus essential oillipid nanoparticleswound healing

Identifiers

PMID29343956
PMCPMC5747963
OpenAlexW2777683769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.