Evidence map›Paper›PMID 29343862›Full record

ArticleScientific reports2018

Angiotensin II Overstimulation Leads to an Increased Susceptibility to Dilated Cardiomyopathy and Higher Mortality in Female Mice.

Sophie Mathieu, Nabil El Khoury, Katy Rivard, Pierre Paradis, Mona Nemer, Céline Fiset

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. RAAS: A Convergent Player in Ischemic Heart Failure and Cancer.International journal of molecular sciences · 2021
    Review
  9. Sex differences in cardiovascular actions of the renin-angiotensin system.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sophie MathieuResearch Center, Montreal Heart Institute, 5000 Bélanger, Montréal, Québec, Canada.
Nabil El KhouryResearch Center, Montreal Heart Institute, 5000 Bélanger, Montréal, Québec, Canada.
Katy RivardResearch Center, Montreal Heart Institute, 5000 Bélanger, Montréal, Québec, Canada.
Pierre ParadisLady Davis Institute, McGill University, Montreal, Québec, Canada.
Mona NemerOttawa University, Ottawa, Ontario, Canada.
Céline FisetResearch Center, Montreal Heart Institute, 5000 Bélanger, Montréal, Québec, Canada. celine.fiset@umontreal.ca.
Montreal Heart Institute · CAUniversité de Montréal · CAMcGill University · CAUniversity of Ottawa · CA

Funding

CIHR MOP-89934
6 · The paper itself

Abstract

Heart failure (HF) is associated with high mortality and affects men and women differently. The underlying mechanisms for these sex-related differences remain largely unexplored. Accordingly, using mice with cardiac-specific overexpression of the angiotensin II (ANGII) type 1 receptor (AT1R), we explored male-female differences in the manifestations of hypertrophy and HF. AT1R mice of both sexes feature electrical and Ca

Indexed as

Angiotensin IIAnimalsCalciumCardiomegalyCardiomyopathy, DilatedDiastoleFemaleHeartHeart FailureMaleMiceMice, Inbred C57BLReceptor, Angiotensin, Type 1Sarcoplasmic ReticulumVentricular Function, LeftAngiotensin IICalciumReceptor, Angiotensin, Type 1

Identifiers

PMID29343862
PMCPMC5772611
OpenAlexW2782695613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.