Evidence map›Paper›PMID 29343837›Full record

ReviewBone marrow transplantation2018

Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT.

David Buchbinder, Debra Lynch Kelly, Rafael F Duarte, Jeffery J Auletta, Neel Bhatt, Michael Byrne, Zachariah DeFilipp, Melissa Gabriel, Anuj Mahindra, Maxim Norkin and 37 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Bone marrow transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Guideline
  2. Computerized programs for cancer survivors with cognitive problems: a systematic review.Journal of cancer survivorship : research and practice · 2019
    Pooled it
  3. Trial
  4. Prevalence of Ototoxicity Following Hematopoietic Stem Cell Transplantation in Pediatric Patients.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Trial
  5. Cognitive Function and Quality of Life in Vorinostat-Treated Patients after Matched Unrelated Donor Myeloablative Conditioning Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 20 institutions in 9 countries.

David BuchbinderDivision of Pediatrics Hematology, Children's Hospital of Orange County, Orange, CA, USA. dbuchbinder@choc.org.
Debra Lynch KellyShands HealthCare and University of Florida, Gainesville, FL, USA.
Rafael F DuarteUniversity Hospital Puerta de Hierro, Madrid, Spain.
Jeffery J AulettaBlood and Marrow Transplant Program and Host Defense Program, Divisions of Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.
Neel BhattCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Michael ByrneVanderbilt University Medical Center, Nashville, TN, USA.
Zachariah DeFilippBlood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, USA.
Melissa GabrielThe Children's Hospital at Westmead, Westmead, NSW, Australia.
Anuj MahindraScripps Blood & Marrow Transplant Program, La Jolla, CA, USA.
Maxim NorkinDivision of Pediatrics Hematology, Children's Hospital of Orange County, Orange, CA, USA.
Helene SchoemansUniversity Hospital of Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7568-8239
Ami J ShahDivision of Stem Cell Transplantation and Regenerative Medicine, Lucille Packard Children's Hospital, Stanford School of Medicine, Palo Alto, CA, USA.
Ibrahim AhmedRainbow Babies and Children's Hospital, Cleveland, OH, USA.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
Grzegorz W BasakMedical University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0003-3858-8180
Sara BeattieDepartment of Psychosocial Oncology and Rehabilitation, Tom Baker Cancer Centre, Calgary, AB, Canada.
Sita BhellaDepartment of Medicine, School of Medicine, Queen's University, Kingston, ON, K7L 3N6, Canada.
Christopher BredesonThe Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Nancy BuninChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Jignesh DalalDivision of Pediatric Hem/Onc/BMT, Children's Mercy Kansas City, Kansas City, Missouri; UMKC School of Medicine, Kansas City, MO, USA.
Andrew DalyTom Baker Cancer Centre, Calgary, AB, Canada.
James GajewskiOregon Health and Science University, Portland, OR, USA.
Robert Peter GaleHematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-9156-1676
John GalvinDivision of Hematology/Oncology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mehdi HamadaniCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Robert J HayashiDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Kehinde AdekolaDivision of Hematology/Oncology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jason LawTufts University Medical Center, Boston, MA, USA.
Catherine J LeeUtah Blood and Marrow Transplant Program Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Jane LiesveldDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Adriana K MaloneTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Arnon NaglerHematology Division and BMT, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Seema NaikTexas Transplant Institute, San Antonino, TX, USA.
Taiga NishihoriDepartment of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-2621-7924
Susan K ParsonsTufts University Medical Center, Boston, MA, USA.
Angela ScherwathDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hannah-Lise SchofieldThe Pennsylvania State University, University Park, PA, USA.
Robert SoifferDana Farber Cancer Institute, Boston, MA, USA.
Jeff SzerDepartment Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-6783-2301
Ida TwistThe Children's Hospital at Westmead, Westmead, NSW, Australia.
Anne B WarwickDepartment of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, USA.
Baldeep M WirkDivision of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA, USA.
Jean YiDivision of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA, USA.
Minoo BattiwallaHematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, USA.
Mary D E FlowersClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Bipin SavaniVanderbilt University Medical Center, Nashville, TN, USA.
Bronwen E ShawCIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · USChildren's Hospital at Westmead · AUChildren's Hospital of Orange County · USChildren's Mercy Hospital · USNorthwestern University · USSeattle Cancer Care Alliance · USTufts University · USVanderbilt University Medical Center · USChildren's Hospital of Philadelphia · USCHRISTUS Transplant Institute · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USHospital Universitario Puerta de Hierro Majadahonda · ESIcahn School of Medicine at Mount Sinai · USImperial College London · GBLucile Packard Children's Hospital · USMassachusetts General Hospital · USMedical University of Warsaw · PLMoffitt Cancer Center · USNational Heart Lung and Blood Institute · US

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT. In this review, we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and to help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Lastly, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae following HCT.

Indexed as

Bone Marrow TransplantationCognitive DysfunctionHematopoietic Stem Cell TransplantationHumansLong Term Adverse EffectsQuality of LifeRisk FactorsTransplant Recipients

Identifiers

PMID29343837
PMCPMC5985976
OpenAlexW2783631497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.