Evidence map›Paper›PMID 29343764›Full record

ArticleNature communications2018

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Xia Jiang, Paul F O'Reilly, Hugues Aschard, Yi-Hsiang Hsu, J Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry and 94 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 15 pooled it
32.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 15 syntheses or guidelines pooled it, 395 citations in OpenAlex.

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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

104 authors at 20 institutions in 11 countries.

Xia JiangProgram in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA.
Paul F O'ReillyDepartment of Social Genetic & Developmental Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK.
Hugues AschardProgram in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA.ORCID http://orcid.org/0000-0003-0907-2548
Yi-Hsiang HsuInstitute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.
J Brent RichardsDepartments of Medicine, Human Genetics, Epidemiology and Biostatistics, 3755 Côte Ste-Catherine Road, Suite H-413 Montréal, Québec, H3T 1E2, Canada.ORCID http://orcid.org/0000-0002-3746-9086
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine Stanford, Stanford, CA, 94305, USA.
David KarasikInstitute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.
Stefan PilzDepartment of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Diane BerryPopulation, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK.
Bryan KestenbaumKidney Research Institute, Division of Nephrology, 325 Ninth Avenue, Seattle, WA, 98104, USA.
Jusheng ZhengMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Jianan LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Eleni SofianopoulouDepartment of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Elizabeth A StreetenGenetics and Personalized Medicine Program, University of Maryland School of Medicine, Howard Hall Room 567, Baltimore, MD, 21201, USA.
Demetrius AlbanesMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
Pamela L LutseyDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA.
Lu YaoDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA.
Weihong TangDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA.
Michael J EconsDepartment of Medicine, Indiana University, Endocrinology, 1120W Michigan Street, Indianapolis, IN, 46202-5124, USA.
Henri WallaschofskiInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17489, Greifswald, Germany.
Henry VölzkeDZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, 13316, Berlin, Germany.
Ang ZhouCentre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, 5001, SA, Australia.
Chris PowerPopulation, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK.
Mark I McCarthyOxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK.ORCID http://orcid.org/0000-0002-4393-0510
Erin D MichosDivision of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Stephanie J WeinsteinMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
Neal D FreedmanMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
Wen-Yi HuangOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
Natasja M Van SchoorDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, De Boelelaan 1089a, 1081 HV, Amsterdam, The Netherlands.
Nathalie van der VeldeErasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
Lisette C P G M de GrootDepartment of Human Nutrition, Wageningen University, PO-box 17, 6700 AA, Wageningen, The Netherlands.ORCID http://orcid.org/0000-0003-2778-2789
Anke EnnemanErasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.
Sarah L BoothVitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
Ramachandran S VasanFramingham Heart Study, 73 Mt. Wayte Avenue, Framingham, MA, 01702, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.ORCID http://orcid.org/0000-0002-0703-0742
Yanhua ZhouDepartment of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.
Samuli RipattiStatistical and Translational Genetics, University of Helsinki, Tukholmankatu 8, Building, Biomedicum, Helsinki 2U, Finland.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Vita Stråket 11, Gothenburg, 41345, Sweden.
Liesbeth VandenputDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Vita Stråket 11, Gothenburg, 41345, Sweden.
Mattias LorentzonDepartment of Geriatric Medicine, University of Gothenburg and Sahlgrenska University Hospital, Mölndal, 43180, Sweden.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, P.O. Box 20, Tukholmankatu, 8 B 00014, Finland.
M Kyla SheaVitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
Denise K HoustonSticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Kurt K LohmanDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Luigi FerrucciLongitudinal Studies Section, Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, 21225, USA.
Munro PeacockDepartment of Medicine, Indiana University, Endocrinology, 1120W Michigan Street, Indianapolis, IN, 46202-5124, USA.
Christian GiegerGerman Research Center for Environmental Health, Molecular Epidemiology, AME, Ingolstädter Landstr 1, D-85764, Neuherberg, Germany.
Marian BeekmanMolecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0585-6206
Eline SlagboomMolecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Joris DeelenMolecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-4483-3701
Diana van HeemstGerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Marcus E KleberVth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer1, 68167, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Winfried MärzVth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer1, 68167, Mannheim, Germany.
Ian H de BoerDivision of Nephrology and Kidney Research Institute, University of Washington, 325 ninth Avenue, Washington, DC, 98104, USA.
Alexis C WoodUSDA/ARS Children's Nutrition Research Center, 1100 Bates Avenue, Houston, TX, 77071, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Stephen S RichDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA.
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Ave S., Nashville, TN, 37232, USA.
Martin den HeijerErasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
Marjo-Riitta JarvelinEpidemiology and Biostatistics School of Public Health, Imperial College London, 156 Norfolk Place, St. Mary's Campus, London, UK W2 1PG, UK.
Alana CavadinoPopulation, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK.
Peter K JoshiCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0002-6361-5059
James F WilsonCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0001-5751-9178
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, the University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-9405-9550
Lars LindDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Karl MichaëlssonDepartment of Surgical Sciences, Uppsala University, Dag Hammarskjöldsv 14 B, Uppsala Science Park, 751 85, Uppsala, Sweden.
Stella TrompetGerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
M Carola ZillikensErasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
Andre G UitterlindenErasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
Fernando RivadeneiraErasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Linda BroerErasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
Lina ZgagaDepartment of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin, Dublin 24, D02 PN40, Ireland.
Harry CampbellCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.
Evropi TheodoratouCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.
Susan M FarringtonInstitute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0001-5955-7389
Maria TimofeevaInstitute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Malcolm G DunlopInstitute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Ana M ValdesThe Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Westminster Bridge Road, London, SE1 7EH, UK.
Emmi TikkanenFIMM-Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, P.O. Box 20, FI-00014, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
Vera MikkiläScience Adviser at Academy of Finland, Hakaniemenranta 6, PO Box 131, FI-00531, Helsinki, Finland.
M Arfan IkramErasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University Avenue, Glasgow, G12 8QQ, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Thomas E GundersenVitas AS, Gaustadaleen 21, N-0349, Oslo, Norway.
Kay-Tee KhawDepartment of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Adam S ButterworthDepartment of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
John DaneshDepartment of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Timothy SpectorThe Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Westminster Bridge Road, London, SE1 7EH, UK.
Thomas J WangDivision of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute, 2220 Pierce Avenue 383 Preston Research Building, Nashville, TN, 37232-6300, USA.
Elina HyppönenPopulation, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK. elina.hypponen@unisa.edu.au.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA. kiel@hsl.harvard.edu.
University of Cambridge · GBErasmus MC · NLWestern General Hospital · GBLeiden University Medical Center · NLBoston University · USNational Cancer Institute · USWake Forest University · USHarvard University · USKing's College London · GBUniversity of Helsinki · FIUniversity of Minnesota · USUppsala University · SEBroad Institute · USIndiana University – Purdue University Indianapolis · USMedical University of Graz · ATTampere University · FITufts University · USUniversitätsmedizin Greifswald · DEUniversity College London · GBUniversity of Gothenburg · SE

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
Identifying Osteoporosis Genes by Whole Genome Sequencing and Functional Validation in Zebra FishR01AR072199 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI HSU, YI-HSIANG · 2017 to 2022
$3.2M
Parathyroid Hormone: Genetic Architecture and Clinical ConsequencesK01DK109019 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROBINSON-COHEN, CASSIANNE · 2016 to 2018
$423k
British Heart Foundation PG/09/023/26806British Heart Foundation RG/08/014/24067Cancer Research UK 12076Cancer Research UK 14136Cancer Research UK 18927Cancer Research UK 22804Department of Health PHCS/C4/4/016Medical Research Council G0401527Medical Research Council G0600237Medical Research Council G0600329Medical Research Council G0601653Medical Research Council G1000143Medical Research Council G1001799Medical Research Council MC_PC_U127527198Medical Research Council MC_PC_U127561128Medical Research Council MC_U127527198Medical Research Council MC_UU_00007/1Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5Medical Research Council MR/K018647/1Medical Research Council MR/L003120/1Medical Research Council MR/N003284/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/N015746/1NCATS NIH HHS UL1 TR001881NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR072199NIDDK NIH HHS K01 DK109019NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10

Indexed as

AmidohydrolasesAutoimmune DiseasesCohort StudiesFemaleGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideVesicular Transport ProteinsVitamin DWhite People25-hydroxyvitamin DAmidohydrolasesSEC23A protein, humanVesicular Transport ProteinsVitamin D

Identifiers

PMID29343764
PMCPMC5772647
OpenAlexW2783489228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.