ArticleScientific reports2018
Sac7 and Rho1 regulate the white-to-opaque switching in Candida albicans.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Influence of Ubiquitin Mutations over Molecular Markers Contributing to Pathogenesis of Candida albicans.Cell biochemistry and biophysics · 2025Article
- Sdd3 regulates the biofilm formation ofmBio · 2025Article
- Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates.PloS one · 2023Article
- Application of the Mutant Libraries forInternational journal of molecular sciences · 2022Review
- Inactivating the mannose-ethanolamine phosphotransferase Gpi7 confers caspofungin resistance in the human fungal pathogenCell surface (Amsterdam, Netherlands) · 2021Article
- Mechanism of Candida pathogenesis: revisiting the vital drivers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- A Set of Diverse Genes Influence the Frequency of White-Opaque Switching inG3 (Bethesda, Md.) · 2020Article
- Genome-wide piggyBac transposon-based mutagenesis and quantitative insertion-site analysis in haploid Candida species.Nature protocols · 2020Article
- Lrg1 Regulates β (1,3)-Glucan Masking in Candida albicans through the Cek1 MAP Kinase Pathway.mBio · 2019Article
- Protein-Protein Interactions inFrontiers in microbiology · 2019Review
- Face/Off: The Interchangeable Side ofFrontiers in cellular and infection microbiology · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans cells homozygous at the mating-type locus stochastically undergo the white-to-opaque switching to become mating-competent. This switching is regulated by a core circuit of transcription factors organized through interlocking feedback loops around the master regulator Wor1. Although a range of distinct environmental cues is known to induce the switching, the pathways linking the external stimuli to the central control mechanism remains largely unknown. By screening a C. albicans haploid gene-deletion library, we found that SAC7 encoding a GTPase-activating protein of Rho1 is required for the white-to-opaque switching. We demonstrate that Sac7 physically associates with Rho1-GTP and the constitutively active Rho1
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