ArticleScientific reports2018
The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05180617 (Feasibility of Music Therapy, Neural Processing and Reduction of Craving in Community Substance Misuse Treatment Services), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of Music Therapy, Neural Processing and Reduction of Craving in Community Substance Misuse Treatment Services (CSMTS)
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Do mindfulness-based interventions change brain function in people with substance dependence? A systematic review of the fMRI evidence.BMC psychiatry · 2023Pooled it
- Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.Addiction biology · 2021Pooled it
- Brain regulation training improves emotional competences in patients with alcohol use disorder.Social cognitive and affective neuroscience · 2024Trial
- Anterior Cingulate Cortex Implants for Alcohol Addiction: A Feasibility Study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Trial
- A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction.Scientific reports · 2018Trial
- The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions.Annual review of psychology · 2026Review
- The reducing effect of visuospatial cognitive load on alcohol craving in problematic drinkers.Frontiers in psychology · 2026Article
- Alcohol cue processing alters delta-band functional connectivity and theta-band network topology in alcohol use disorder: a task-based EEG study.BMC psychiatry · 2025Article
- Research on drug addiction detection based on AR-TSNET with bimodal EEG-NIRS.Biomedical engineering online · 2025Article
- Emerging neuromodulation treatments for opioid and stimulant use disorders.Frontiers in human neuroscience · 2025Review
- Facial expression analysis and machine learning for objective assessment of alcohol craving in alcohol use disorder: a study protocol.Frontiers in psychiatry · 2025Article
- A moderated mediation model in assessing links between rumination, emotional reactivity, and suicidal risk in alcohol use disorder.Frontiers in psychiatry · 2025Article
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- Associative memory in alcohol-related contexts: An fMRI study with young binge drinkers.Journal of psychopharmacology (Oxford, England) · 2024Article
- Neural signatures of imaginary motivational states: desire for music, movement and social play.Brain topography · 2024Article
- Multimodal Assessment of Smoking cue Reactivity During a Smoking Cue Exposure Task.Clinical EEG and neuroscience · 2024Article
- Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review.Psychopharmacology · 2024Review
- Development and standardization of Indian Alcohol Photo Stimuli (IAPS) for cue-reactivity paradigms in patients with alcohol use disorder.Indian journal of psychiatry · 2024Article
- Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake.Neurobiology of stress · 2023Article
- Music therapy, neural processing, and craving reduction: an RCT protocol for a mixed methods feasibility study in a Community Substance Misuse Treatment Service.Addiction science & clinical practice · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus accumbens (NAcc), posterior cingulate cortex (PCC) and pregenual anterior cingulate cortex (pgACC), etc. In this study, we combine these two imaging techniques to investigate a group of alcohol-addicted patients and provide convergent evidence for the neural correlates of craving not only in alcohol but substance abuse in general. We observe abnormal BOLD signal levels in the dACC, NAcc, pgACC, PCC, amygdala, and parahippocampus (PHC) in a cue-reactivity fMRI experiment. These findings are consistent with increased beta-band activity in the dACC and pgACC in resting-state EEG. We further observe desynchronization characterized by decreased functional connectivity in cue-based fMRI and hypersynchronization characterized by increased functional connectivity between these regions in the theta frequency band. The results of our study show a consistent pattern of alcohol craving elicited by external cues and internal desires. Given the advantage of superior spatial and temporal resolution, we hypothesize a "central craving network" that integrates the different aspects of alcohol addiction into a unified percept.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.