Evidence map›Paper›PMID 29343731›Full record

ArticleScientific reports2018

Impact of tissue kinetic heterogeneity on PET quantification: case study with the L-[1-

Mattia Veronese, Alessandra Bertoldo, Giampaolo Tomasi, Carolyn Beebe Smith, Kathleen C Schmidt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Increased rates of brain protein synthesis during [N1,N2] sleep: L-[1-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  3. Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Substitution of venous for arterial blood sampling in the determination of regional rates of cerebral protein synthesis with L-[1-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mattia VeroneseSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, Maryland, USA.
Alessandra BertoldoDepartment of Information Engineering, University of Padova, Padova, Italy.
Giampaolo TomasiSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, Maryland, USA.
Carolyn Beebe SmithSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, Maryland, USA.
Kathleen C SchmidtSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, Maryland, USA. KSchmidt@mail.nih.gov.

Funding

Mathematical and Statistical Analysis Techniques for in Vivo Imaging StudiesZIAMH002935 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BEEBE SMITH, CAROLYN · 2012 to 2019
$1.4M
Wellcome Trust
6 · The paper itself

Abstract

Functional quantification with PET is generally based on modeling that assumes tissue regions are kinetically homogeneous. Even in regions sufficiently small to approach homogeneity, spillover due to resolution limitations of PET scanners may introduce heterogeneous kinetics into measured data. Herein we consider effects of kinetic heterogeneity at the smallest volume accessible, the single image voxel. We used L-[1-

Indexed as

BrainCarbon RadioisotopesHumansKineticsLeucineModels, BiologicalPositron-Emission TomographyProtein BiosynthesisTomography, X-Ray ComputedCarbon-11Carbon RadioisotopesLeucine

Identifiers

PMID29343731
PMCPMC5772379

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.