ArticleScientific reports2018
Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 73 citations in OpenAlex.
- Dual-Function Sol-Gel Antibacterial Materials with Biphasic Octenidine Release for Decontamination and Long-Term Protection.ACS omega · 2026Article
- Evaluation of a long-term antimicrobial dental adhesive via in vitro biodegradation and in vivo rodent secondary caries models.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Unwinding the Threads of Mesoporous Silica Nanoparticles as Cutting-edge for the Management of Inflammation: An Updated Review.Current pharmaceutical biotechnology · 2025Review
- Designing Antibacterial-Based Quaternary Ammonium Coatings (Surfaces) or Films for Biomedical Applications: Recent Advances.International journal of molecular sciences · 2024Review
- Water-dispersable photoreactors based on core-shell mesoporous silica particles.Scientific reports · 2024Article
- Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors for Tendon Tissue Engineering.ACS materials Au · 2023Article
- One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication.ACS applied bio materials · 2023Article
- Mesoporous silicas in materials engineering: Nanodevices for bionanotechnologies.Materials today. Bio · 2022Review
- Octenidine's Efficacy: A Matter of Interpretation or the Influence of Experimental Setups?Antibiotics (Basel, Switzerland) · 2022Article
- Rapid synthesis of drug-encapsulated films by evaporation-induced self-assembly for highly-controlled drug release from biomaterial surfaces.Journal of materials chemistry. B · 2022Article
- Preparation of Hybrid Sol-Gel Materials Based on Living Cells of Microorganisms and Their Application in Nanotechnology.Nanomaterials (Basel, Switzerland) · 2022Review
- Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications.Journal of nanobiotechnology · 2022Review
- Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics.Bioactive materials · 2022Review
- Antimicrobial and Antibiofilm Properties of Bioceramic Materials in Endodontics.Materials (Basel, Switzerland) · 2021Review
- Unraveling the mechanism of octenidine and chlorhexidine on membranes: Does electrostatics matter?Biophysical journal · 2021Article
- Sulfamic acid pyromellitic diamide-functionalized MCM-41 as a multifunctional hybrid catalyst for melting-assisted solvent-free synthesis of bioactive 3,4-dihydropyrimidin-2-(1H)-ones.Scientific reports · 2021Article
- Review
- Antimicrobial antidegradative dental adhesive preserves restoration-tooth bond.Dental materials : official publication of the Academy of Dental Materials · 2020Article
- Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system.Drug delivery and translational research · 2020Article
- Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis.Theranostics · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.