ArticleProceedings of the National Academy of Sciences of the United States of America2018
Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026Article
- A High-Resolution Transcriptomic Atlas of Cell Types in the Ventral Visual Thalamus.Journal of neurochemistry · 2026Article
- Fn14 is an activity-dependent, Bmal1-regulated cytokine receptor that induces rod-like microglia and restricts neuronal activity in vivo.Cell reports · 2026Article
- Slc6a9 is distributed in glial cells and neurons across several nervous system regions, whereas Slc6a5 is more restricted to neurons in the caudal brain.BMC neuroscience · 2026Article
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- SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus.Biology open · 2025Article
- AIP1 Regulates Ocular Angiogenesis Via NLRP12-ASC-Caspase-8 Inflammasome-Mediated Endothelial Pyroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A novel developmental critical period of orexinergic signaling in the primary visual thalamus.iScience · 2024Article
- Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia.Nature neuroscience · 2024Article
- The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian functionbioRxiv : the preprint server for biology · 2024Article
- STAB2: an updated spatio-temporal cell atlas of the human and mouse brain.Nucleic acids research · 2024Article
- Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling.Animal cells and systems · 2024Article
- Article
- Single-cell profiling of glial cells from the mouse amygdala under opioid dependent and withdrawal states.iScience · 2023Article
- Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly.Cell reports · 2023Article
- Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.Nature reviews. Neurology · 2023Review
- Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.Cell reports · 2022Article
- Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process.Cell reports · 2022Article
- Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.Nature communications · 2022Article
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9 authors.
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Abstract
Coordinated changes in gene expression underlie the early patterning and cell-type specification of the central nervous system. However, much less is known about how such changes contribute to later stages of circuit assembly and refinement. In this study, we employ single-cell RNA sequencing to develop a detailed, whole-transcriptome resource of gene expression across four time points in the developing dorsal lateral geniculate nucleus (LGN), a visual structure in the brain that undergoes a well-characterized program of postnatal circuit development. This approach identifies markers defining the major LGN cell types, including excitatory relay neurons, oligodendrocytes, astrocytes, microglia, and endothelial cells. Most cell types exhibit significant transcriptional changes across development, dynamically expressing genes involved in distinct processes including retinotopic mapping, synaptogenesis, myelination, and synaptic refinement. Our data suggest that genes associated with synapse and circuit development are expressed in a larger proportion of nonneuronal cell types than previously appreciated. Furthermore, we used this single-cell expression atlas to identify the Prkcd-Cre mouse line as a tool for selective manipulation of relay neurons during a late stage of sensory-driven synaptic refinement. This transcriptomic resource provides a cellular map of gene expression across several cell types of the LGN, and offers insight into the molecular mechanisms of circuit development in the postnatal brain.
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