Evidence map›Paper›PMID 29343637›Full record

ArticleDevelopment (Cambridge, England)2018

Tyrosine phosphorylation and proteolytic cleavage of Notch are required for non-canonical Notch/Abl signaling in

Ramakrishnan Kannan, Eric Cox, Lei Wang, Irina Kuzina, Qun Gu, Edward Giniger

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. ACS omega · 2020
    Article
  6. Abl signaling directs growth of a pioneer axon inMolecular biology of the cell · 2020
    Article
  7. Review
  8. Review
  9. Decoding the PTM-switchboard of Notch.Biochimica et biophysica acta. Molecular cell research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ramakrishnan KannanNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7717-0516
Eric CoxNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Lei WangFred Hutchinson Cancer Research Center, 1100 Fairview Ave, N., Seattle, WA 98109, USA.
Irina KuzinaNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Qun GuNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Edward GinigerNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA ginigere@ninds.nih.gov.ORCID 0000-0002-8340-6158
National Institutes of Health · USFred Hutch Cancer Center · US

Funding

Mechanisms of axon guidance during developmentZIANS003013 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GINIGER, EDWARD · 2009 to 2025
$17.2M
Mechanisms of axon guidance during developmentZ01NS003013 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GINIGER, EDWARD · 2005 to 2008
$2.0M
Intramural NIH HHS Z01 NS003013
6 · The paper itself

Abstract

Notch signaling is required for the development and physiology of nearly every tissue in metazoans. Much of Notch signaling is mediated by transcriptional regulation of downstream target genes, but Notch controls axon patterning in

Indexed as

Amino Acid SequenceAnimalsAxon GuidanceBinding SitesDrosophila melanogasterDrosophila ProteinsGlucosyltransferasesGlycosylationGuanine Nucleotide Exchange FactorsLigandsModels, NeurologicalNerve Tissue ProteinsPhosphoproteinsPhosphorylationProtein Serine-Threonine KinasesProtein-Tyrosine KinasesAbl protein, Drosophiladab protein, DrosophilaDrosophila ProteinsGlucosyltransferasesGuanine Nucleotide Exchange FactorsLigandsNerve Tissue ProteinsN protein, DrosophilaPhosphoproteinsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesReceptors, NotchRumi protein, Drosophilatrio protein, DrosophilaTyrosineAblAxon guidanceDisabledNotchProteolytic cleavageTrioTyrosine phosphorylation

Identifiers

PMID29343637
PMCPMC5825841
OpenAlexW2781412274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.