Evidence map›Paper›PMID 29343631›Full record

ArticleJournal of the Royal Society, Interface2018

Stochastic resonances in a distributed genetic broadcasting system: the NF

Zhipeng Wang, Davit A Potoyan, Peter G Wolynes

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhipeng WangDepartment of Chemistry, Rice University, Houston, TX 77005, USA.
Davit A PotoyanDepartment of Chemistry, Rice University, Houston, TX 77005, USA potoyan@iastate.edu.ORCID 0000-0002-5860-1699
Peter G WolynesDepartment of Chemistry, Rice University, Houston, TX 77005, USA.

Funding

STRUCTURE AND STABILITY OF IKB/NF-KB COMPLEXESP01GM071862 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 2006 to 2016
$14.9M
NIGMS NIH HHS P01 GM071862
6 · The paper itself

Abstract

Gene regulatory networks must relay information from extracellular signals to downstream genes in an efficient, timely and coherent manner. Many complex functional tasks such as the immune response require system-wide broadcasting of information not to one but to many genes carrying out distinct functions whose dynamical binding and unbinding characteristics are widely distributed. In such broadcasting networks, the intended target sites are also often dwarfed in number by the even more numerous non-functional binding sites. Taking the genetic regulatory network of NF

Indexed as

Gene Regulatory NetworksModels, GeneticResponse ElementsAnimalsDNAHumansI-kappa B KinaseKineticsNF-kappa BStochastic ProcessesDNAI-kappa B KinaseNF-kappa Bchip-seq binding sitesgene regulatory networksgenome-wide broadcasting networkstochastic resonance

Identifiers

PMID29343631
PMCPMC5805984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.