ArticleScience translational medicine2018
Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 123 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 2 pooled it
20.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of EsoCheck Compared to Biopsies and Brush Cytology During Endoscopy for Evaluation of Eosinophilic Esophagitis.
Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans
Who cites it
123 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Unsedated transnasal endoscopy for the detection of Barrett's esophagus: systematic review and meta-analysis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Pooled it
- Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Guideline
- Understanding the Epigenetic Landscape of Barrett's Esophagus and Esophageal Cancer: A Review of Current Findings, Caveats and Future Directions.Genes, chromosomes & cancer · 2026Review
- Biomarker Use in Barrett's Esophagus Surveillance.The American journal of gastroenterology · 2026Review
- Development, characterization, and inter-laboratory validation of methylated human cell free DNA candidate reference materials.Clinical epigenetics · 2026Article
- Screening for Barrett's esophagus and esophageal adenocarcinoma: recent advances and next steps.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Review
- Pilot study of EsoCheck/EsoGuard for detecting Barrett's esophagus in high-risk patients undergoing hiatal hernia repair.Surgical endoscopy · 2026Article
- Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026Review
- Diagnostic and Prognostic Biomarkers for Barrett's Esophagus.Gastroenterology clinics of North America · 2026Review
- Nonendoscopic Detection of Barrett's Esophagus on Patients Without Gastroesophageal Reflux Disease Symptoms.The American journal of gastroenterology · 2026Article
- Current Concepts for Diagnosing Non-Dysplastic and Dysplastic Barrett's Esophagus.Gastrointestinal endoscopy clinics of North America · 2026Review
- Swallowing the Future of Cancer Prevention: Could EsoGuard Revolutionize the Fight Against Esophageal Cancer?Gastro hep advances · 2026Article
- Liquid Biopsy and Nonendoscopic Biomarkers for Precision Early Detection of Esophageal Cancer: Evidence, Risk Stratification and Translational Challenges.Journal of Cancer · 2026Review
- Nonendoscopic Screening for Barrett's Esophagus: Current Methods, Evidence, and Future Directions.Gastro hep advances · 2026Review
- The biology and therapeutic implications of heterogeneity in Barrett oesophagus and oesophageal adenocarcinoma.Nature reviews. Clinical oncology · 2026Review
- Emerging Biomarkers for Managing Barrett's Esophagus.Gastrointestinal endoscopy clinics of North America · 2026Review
- Associations Between Non-Genetic Risk Factors and DNA Methylation Alterations in Barrett's Esophagus and Its Progression to Esophageal Adenocarcinoma.International journal of molecular sciences · 2025Review
- Role of Endoscopy in the Diagnosis and Management of Esophageal Cancer.Journal of clinical medicine · 2025Review
- Swallowable expandable fibrous capsules for nonendoscopic sampling of esophageal cells.Science advances · 2025Article
- Advances in Epigenomic Sequencing and Their Applications in Cancer Diagnostics.Precision chemistry · 2025Review
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 1 country.
Helen R MoinovaDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.ORCID 0000-0001-5123-7671
Thomas LaFramboiseCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
James D LutterbaughDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Apoorva Krishna ChandarDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
John DumotDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Ashley FaulxDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Wendy BrockDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Omar De la Cruz CabreraDepartment of Mathematical Sciences, Kent State University, Kent, OH 44242, USA.ORCID 0000-0002-7317-2968
Kishore GudaCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-8218-7830
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-6190-9304
Prasad G IyerBarrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-9822-1420
Marcia I CantoDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Jean S WangDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nicholas J ShaheenCenter for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Prashanti N ThotaDigestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Joseph E WillisCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. sxm10@cwru.edu josephe.willis@uhhospitals.org amitabh.chak@uhhospitals.org.ORCID 0000-0003-1782-886X
Amitabh ChakDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. sxm10@cwru.edu josephe.willis@uhhospitals.org amitabh.chak@uhhospitals.org.ORCID 0000-0002-0021-7862
Sanford D MarkowitzDepartment of Medicine, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. sxm10@cwru.edu josephe.willis@uhhospitals.org amitabh.chak@uhhospitals.org.ORCID 0000-0001-5369-5254
University Hospitals of Cleveland · USCase Western Reserve University · USCleveland Clinic · USJohns Hopkins University · USKent State University · USMayo Clinic · USUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MTargeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6MWhole Exome Approaches for Esophageal Adenocarcinoma Susceptibility GenesU54CA163060 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHAK, AMITABH, GUDA, KISHORE · 2011 to 2022
$14.0MTranslational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MIdentify and validate novel epigenetic molecular markers for colorectal neoplasmU01CA152756 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY, GUDA, KISHORE · 2010 to 2021
$6.7MTargeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and TreatmentR35CA197442 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2017 to 2023
$6.6MValidation of Methylated Vimentin as a Diagnostic Test for Barrett's EsophagusUH2CA205105 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI WILLIS, JOSEPH EDWARD · 2016 to 2017
$664kValidation of Methylated Vimentin as a Diagnostic Test for Barrett's EsophagusUH3CA205105 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI WILLIS, JOSEPH EDWARD · 2019 to 2020
$653kNCATS NIH HHS UL1 TR000439NCI NIH HHS P30 CA016086NCI NIH HHS P50 CA150964NCI NIH HHS R35 CA197442NCI NIH HHS U01 CA152756NCI NIH HHS U54 CA163060NCI NIH HHS UH2 CA205105NCI NIH HHS UH3 CA205105NIDDK NIH HHS P30 DK089502NIDDK NIH HHS P30 DK097948
Abstract
We report a biomarker-based non-endoscopic method for detecting Barrett's esophagus (BE) based on detecting methylated DNAs retrieved via a swallowable balloon-based esophageal sampling device. BE is the precursor of, and a major recognized risk factor for, developing esophageal adenocarcinoma. Endoscopy, the current standard for BE detection, is not cost-effective for population screening. We performed genome-wide screening to ascertain regions targeted for recurrent aberrant cytosine methylation in BE, identifying high-frequency methylation within the
Indexed as
Barrett EsophagusBiomarkers, TumorCyclin A1DNA MethylationGenetic MarkersHumansBiomarkers, TumorCCNA1 protein, humanCyclin A1Genetic Markers
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT04311970ClinicalTrials.gov
NCT05210049ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.