ArticleDrug metabolism and disposition: the biological fate of chemicals2018
Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D
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In one paragraph
Article in Drug metabolism and disposition: the biological fate of chemicals, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Genetic Variants Associated With the Biochemical Response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2025Trial
- Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.The Journal of clinical endocrinology and metabolism · 2019Trial
- Evaluation of correlations between serum and urinary vitamin D metabolites using LC-MS/MS.Bioscience reports · 2026Article
- Cytosolic sulfotransferases in endocrine disruption.Essays in biochemistry · 2024Review
- Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes.Essays in biochemistry · 2024Review
- Sulfation pathways in the maintenance of functional beta-cell mass and implications for diabetes.Essays in biochemistry · 2024Review
- Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women.Clinical nutrition (Edinburgh, Scotland) · 2024Article
- Metabolism and pharmacokinetics of vitamin D in patients with cystic fibrosis.The Journal of steroid biochemistry and molecular biology · 2023Article
- Separation and identification of monoglucuronides of vitamin DAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health.Nutrients · 2022Review
- Physiologically Based Pharmacokinetic Modeling of Vitamin DDrug metabolism and disposition: the biological fate of chemicals · 2022Article
- Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine.Pharmacological reviews · 2022Review
- SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1.PNAS nexus · 2022Article
- Simultaneous determination of vitamin D metabolites 25(OH)DJournal of mass spectrometry and advances in the clinical lab · 2022Article
- Validation of the 24,25-dihydroxyvitamin DThe Journal of steroid biochemistry and molecular biology · 2022Article
- Circulating Conjugated and Unconjugated Vitamin D Metabolite Measurements by Liquid Chromatography Mass Spectrometry.The Journal of clinical endocrinology and metabolism · 2022Article
- Review
- Vitamin D Metabolism and Guidelines for Vitamin D Supplementation.The Clinical biochemist. Reviews · 2020Review
- Role of glucuronidated 25-hydroxyvitamin D on colon gene expression in mice.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.Nature communications · 2020Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Timothy WongDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Zhican WangDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Brian D ChapronDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Mizuki SuzukiDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Katrina G ClawDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Chunying GaoDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Robert S FotiDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Bhagwat PrasadDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Alenka ChapronDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Justina CalamiaDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Amarjit ChaudhryDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Erin G SchuetzDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Ronald L HorstDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Qingcheng MaoDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Ian H de BoerDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Timothy A ThorntonDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.).
Kenneth E ThummelDepartments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.) thummel@uw.edu.
St. Jude Children's Research Hospital · USUniversity of Washington · USAmgen (United States) · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MXENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5MTOXIC DRUG INTERACTIONS WITH VALPROIC ACIDP01GM032165 · NIGMS · UNIVERSITY OF WASHINGTON · PI RETTIE, ALLAN EDWARD · 1985 to 2012
$18.3MPharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6MPharmacogenetics in Rural and Underserved PopulationsU01GM092676 · NIGMS · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G., THUMMEL, KENNETH E. · 2010 to 2014
$9.9MNRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4MHormonal Regulation of Human CYP3AR01GM063666 · NIGMS · UNIVERSITY OF WASHINGTON · PI THUMMEL, KENNETH E. · 2002 to 2017
$5.3MInstitute of Translational Health SciencesTL1TR000422 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$2.1MVariation of vitamin D metabolism and regulatory genes in the Yup’ik populationF32GM119237 · NIGMS · UNIVERSITY OF WASHINGTON · PI CLAW, KATRINA G · 2016 to 2018
$174kNCATS NIH HHS TL1 TR000422NCATS NIH HHS TL1 TR002318NCI NIH HHS P30 CA021765NIEHS NIH HHS P30 ES007033NIGMS NIH HHS F32 GM119237NIGMS NIH HHS P01 GM032165NIGMS NIH HHS R01 GM063666NIGMS NIH HHS T32 GM007750NIGMS NIH HHS U01 GM092676NLM NIH HHS HHSN276201200017C
Abstract
Metabolism of 25-hydroxyvitamin D
Indexed as
AdolescentAdultAgedAged, 80 and overCalcifediolChildChild, PreschoolCytochrome P-450 Enzyme SystemFemaleHumansHydroxylationInfantKineticsLiverMaleMiddle Agedalcohol sulfotransferaseCalcifediolCytochrome P-450 Enzyme SystemPregnane X ReceptorReceptors, SteroidSulfatesSulfotransferasesVitamin D
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.