ArticleProceedings. Biological sciences2018
Coadaptation of mitochondrial and nuclear genes, and the cost of mother's curse.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Molecular biology and evolution · 2025Article
- Testing the Mother's Curse Hypothesis in Human Mitochondrial Genome Evolution.Genome biology and evolution · 2025Article
- Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes.Biogerontology · 2024Review
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- Genomic Signatures of Mitonuclear Coevolution in Mammals.Molecular biology and evolution · 2022Article
- Effects of mitochondrial haplotype on pre-copulatory mating success in male fruit flies (Drosophila melanogaster).Journal of evolutionary biology · 2022Article
- Widespread genomic signatures of reproductive isolation and sex-specific selection in the Eastern Yellow Robin, Eopsaltria australis.G3 (Bethesda, Md.) · 2022Article
- Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast.Nature ecology & evolution · 2022Article
- Migration restores hybrid incompatibility driven by mitochondrial-nuclear sexual conflict.Proceedings. Biological sciences · 2022Article
- Adaptive co-evolution of mitochondria and the Y-chromosome: A resolution to conflict between evolutionary opponents.Ecology and evolution · 2021Article
- Mother's curse is pervasive across a large mitonuclearEvolution letters · 2021Article
- Sexually antagonistic coevolution between the sex chromosomes ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mitochondrial-Y chromosome epistasis inProceedings. Biological sciences · 2020Article
- Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Sperm competitive advantage of a rare mitochondrial haplogroup linked to differential expression of mitochondrial oxidative phosphorylation genes.Journal of evolutionary biology · 2019Article
- Temperature-Sensitive Reproduction and the Physiological and Evolutionary Potential for Mother's Curse.Integrative and comparative biology · 2019Article
- Sexual conflict through mother's curse and father's curse.Theoretical population biology · 2019Article
- Genetic Incompatibilities Between Mitochondria and Nuclear Genes: Effect on Gene Flow and Speciation.Frontiers in genetics · 2019Article
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Authors and funding
4 authors.
Funding
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Abstract
Strict maternal inheritance renders the mitochondrial genome susceptible to accumulating mutations that harm males, but are otherwise benign or beneficial for females. This 'mother's curse' effect can degrade male survival and fertility if unopposed by counteracting evolutionary processes. Coadaptation between nuclear and mitochondrial genomes-with nuclear genes evolving to compensate for male-harming mitochondrial substitutions-may ultimately resolve mother's curse. However, males are still expected to incur a transient fitness cost during mito-nuclear coevolution, and it remains unclear how severe such costs should be. We present a population genetic analysis of mito-nuclear coadaptation to resolve mother's curse effects, and show that the magnitude of the 'male mitochondrial load'-the negative impact of mitochondrial substitutions on male fitness components-may be large, even when genetic variation for compensatory evolution is abundant. We also find that the male load is surprisingly sensitive to population size: male fitness costs of mito-nuclear coevolution are particularly pronounced in both small and large populations, and minimized in populations of intermediate size. Our results reveal complex interactions between demography and genetic constraints during the resolution of mother's curse, suggesting potentially widespread species differences in susceptibility to mother's curse effects.
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