Evidence map›Paper›PMID 29343583›Full record

ArticleJournal of virology2018

Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus.

Thanalai Poonsiri, Gareth S A Wright, Michael S Diamond, Lance Turtle, Tom Solomon, Svetlana V Antonyuk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Thanalai PoonsiriMolecular Biophysics Group, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
Gareth S A WrightMolecular Biophysics Group, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Lance TurtleCentre for Global Vaccine Research, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Tom SolomonHealth Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Svetlana V AntonyukMolecular Biophysics Group, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom S.Antonyuk@liverpool.ac.uk.
University of Liverpool · GBHealth Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool · GBWashington University in St. Louis · US

Funding

Department of Health EME/12/205/28Department of Health IS-HPU-1112-10117Department of Health RP-PG-0108-10048Medical Research Council G116/194Medical Research Council MC_PC_15096NIAID NIH HHS HHSN272201400018CWellcome TrustWellcome Trust 205228/Z/16/Z
6 · The paper itself

Abstract

Japanese encephalitis virus (JEV) is a mosquito-transmitted flavivirus that is closely related to other emerging viral pathogens, including dengue virus (DENV), West Nile virus (WNV), and Zika virus (ZIKV). JEV infection can result in meningitis and encephalitis, which in severe cases cause permanent brain damage and death. JEV occurs predominantly in rural areas throughout Southeast Asia, the Pacific Islands, and the Far East, causing around 68,000 cases of infection worldwide each year. In this report, we present a 2.1-Å-resolution crystal structure of the C-terminal β-ladder domain of JEV nonstructural protein 1 (NS1-C). The surface charge distribution of JEV NS1-C is similar to those of WNV and ZIKV but differs from that of DENV. Analysis of the JEV NS1-C structure, with

Indexed as

Crystallography, X-RayEncephalitis Virus, JapaneseHeparinLiposomesProtein DomainsStructure-Activity RelationshipViral Nonstructural ProteinsHeparinLiposomesViral Nonstructural ProteinsJapanese encephalitis virusneutralizing antibodiesnonstructural protein 1protein crystallographyprotein structure-function

Identifiers

PMID29343583
PMCPMC5972899
OpenAlexW2784948692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.