Evidence map›Paper›PMID 29343576›Full record

ArticleJournal of virology2018

Increased Epitope Complexity Correlated with Antibody Affinity Maturation and a Novel Binding Mode Revealed by Structures of Rabbit Antibodies against the Third Variable Loop (V3) of HIV-1 gp120.

Ruimin Pan, Yali Qin, Marisa Banasik, William Lees, Adrian J Shepherd, Michael W Cho, Xiang-Peng Kong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ruimin PanDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, New York, USA.
Yali QinDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.
Marisa BanasikDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.
William LeesInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom.
Adrian J ShepherdInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom.
Michael W ChoDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa, USA mcho@iastate.edu xiangpeng.kong@med.nyu.edu.
Xiang-Peng KongDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, New York, USA mcho@iastate.edu xiangpeng.kong@med.nyu.edu.
Iowa State University · USNew York University · USBirkbeck, University of London · GBInstitute of Structural and Molecular Biology · GB

Funding

Vaccines to Induce Functional Antibodies Targeting the V2 Loop P01AI100151 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WANG, SHIXIA · 2012 to 2017
$15.4M
Structural Evaluation of HIV-1 Envelope GycoproteinP01AI074286 · NIAID · IOWA STATE UNIVERSITY · PI CHO, MICHAEL W · 2008 to 2012
$5.0M
NIAID NIH HHS P01 AI074286NIAID NIH HHS P01 AI100151
6 · The paper itself

Abstract

The third variable (V3) loop of HIV-1 gp120 is an immunodominant region targeted by neutralizing antibodies (nAbs). Despite limited breadth, better characterization of the structural details of the interactions between these nAbs and their target epitopes would enhance our understanding of the mechanism of neutralization and facilitate designing better immunogens to induce nAbs with greater breadth. Recently, we isolated two anti-V3 neutralizing monoclonal antibodies (MAbs), 10A3 and 10A37, from a rabbit immunized with gp120 of the M group consensus sequence. In this study, crystal structures of these MAbs bound to target epitopes were determined. 10A3 binds to the V3 crown (

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibody AffinityAntibody FormationEpitopesHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansNeutralization TestsProtein ConformationRabbitsAntibodies, MonoclonalAntibodies, NeutralizingEpitopesHIV AntibodiesHIV Envelope Protein gp120gp120HIV-1neutralizing antibodyV3V3 loop

Identifiers

PMID29343576
PMCPMC5972897
OpenAlexW2786645873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.