Evidence map›Paper›PMID 29343575›Full record

ArticleJournal of virology2018

High-Resolution Sequencing of Viral Populations during Early Simian Immunodeficiency Virus Infection Reveals Evolutionary Strategies for Rapid Escape from Emerging Env-Specific Antibody Responses.

Sergio Ita, Alison K Hill, Evan C Lam, Fay J Dufort, Xiao Yang, Ruchi Newman, Sivan Leviyang, Ismael B Fofana, Welkin E Johnson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sergio ItaVirology Program, Harvard Medical School, Boston, Massachusetts, USA.
Alison K HillVirology Program, Harvard Medical School, Boston, Massachusetts, USA.
Evan C LamDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5556-2559
Fay J DufortDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Xiao YangViral Genomics Group, Broad Research Institute, Cambridge, Massachusetts, USA.
Ruchi NewmanViral Genomics Group, Broad Research Institute, Cambridge, Massachusetts, USA.
Sivan LeviyangDepartment of Mathematics, Georgetown University, Washington, DC, USA.
Ismael B FofanaDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Welkin E JohnsonDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA welkin.johnson@bc.edu.ORCID https://orcid.org/0000-0001-5991-5414
Boston College · USBroad Institute · USGeorgetown University · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Cross-Species transmission and adaptation of primate lentivirusesR01AI083118 · NIAID · HARVARD MEDICAL SCHOOL · PI JOHNSON, WELKIN E · 2009 to 2019
$4.0M
NIAID NIH HHS R01 AI083118NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Primate lentiviruses, including the human and simian immunodeficiency viruses (HIV and SIV), produce infections marked by persistent, ongoing viral replication. This occurs despite the presence of virus-specific adaptive immune responses, including antibodies targeting the viral envelope glycoprotein (Env), and evolution of antibody-escape variants is a well-documented feature of lentiviral infection. Here, we examined the evolutionary dynamics of the SIV

Indexed as

Antibodies, ViralHigh-Throughput Nucleotide SequencingAnimalsGene Products, envMacaca mulattaSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAntibodies, ViralGene Products, envenvHIVsimian immunodeficiency virusSIVviral fitness

Identifiers

PMID29343575
PMCPMC5972902
OpenAlexW2790893406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.