Evidence map›Paper›PMID 29343566›Full record

ArticleJournal of virology2018

Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques.

Ravi Mahalingam, Benedikt B Kaufer, Werner J D Ouwendijk, Georges M G M Verjans, Colin Coleman, Meredith Hunter, Arpita Das, Brent E Palmer, Eric Clambey, Maria A Nagel and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Ravi MahalingamDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA ravi.mahalingam@ucdenver.edu.
Benedikt B KauferInstitute for Virology, Freie Universität Berlin, Berlin, Germany.
Werner J D OuwendijkDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Georges M G M VerjansDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Colin ColemanDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Meredith HunterDivision of Microbiology, Tulane University, Tulane National Primate Research Center, Covington, Louisiana, USA.
Arpita DasDivision of Microbiology, Tulane University, Tulane National Primate Research Center, Covington, Louisiana, USA.
Brent E PalmerDivision of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Eric ClambeyDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Maria A NagelDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Vicki Traina-DorgeDivision of Microbiology, Tulane University, Tulane National Primate Research Center, Covington, Louisiana, USA.
Tulane University · USUniversity of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · USErasmus University Rotterdam · NLFreie Universität Berlin · DEUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONSP51RR000164 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI VEAZEY, RONALD S. · 1985 to 2011
$100.1M
VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2009 to 2023
$30.3M
Purinergic Signaling in Varicella Zoster Virus VasculopathyR01NS094758 · NINDS · UNIVERSITY OF COLORADO DENVER · PI NAGEL, MARIA ACENA · 2015 to 2018
$1.4M
NCRR NIH HHS P51 RR000164NIA NIH HHS P01 AG032958NIH HHS P51 OD011104NINDS NIH HHS R01 NS094758
6 · The paper itself

Abstract

Simian varicella virus (SVV), the primate counterpart of varicella-zoster virus, causes varicella (chickenpox), establishes latency in ganglia, and reactivates to produce zoster. We previously demonstrated that a recombinant SVV expressing enhanced green fluorescent protein (rSVV.eGFP) is slightly attenuated both in culture and in infected monkeys. Here, we generated two additional recombinant SVVs to visualize infected cells

Indexed as

Gene Expression Regulation, ViralGreen Fluorescent ProteinsHerpesviridae InfectionsMonkey DiseasesOpen Reading FramesVaricellovirusAnimalsCell LineMacaca mulattaViral Proteinsenhanced green fluorescent proteinGreen Fluorescent ProteinsViral ProteinsattenuationGFPSVV

Identifiers

PMID29343566
PMCPMC5972883
OpenAlexW2783831286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.