ReviewClinical cancer research : an official journal of the American Association for Cancer Research2018
2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph
Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 179 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 4 pooled it
36.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
International Pleuropulmonary Blastoma/DICER1 Registry (for PPB, DICER1 and Associated Conditions)
Who cites it
179 citing papers in PubMed, 4 syntheses or guidelines pooled it, 362 citations in OpenAlex.
- DICER1 alterations in thyroid lesions: a systematic review and meta-analysis with clinicopathologic implications.Virchows Archiv : an international journal of pathology · 2026Pooled it
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group.Familial cancer · 2021Guideline
- Guideline
- Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.Acta neuropathologica · 2020Trial
- Emergence of the cancer antigen PRAME as key player in epigenetic dysregulation and renal tumorigenesis.Cell death and differentiation · 2026Article
- Surgical management and molecular diagnosis of pediatric cystic nephroma: a single-center case series with implications forTranslational andrology and urology · 2026Article
- Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine Opportunities in Soft Tissue Sarcomas.International journal of molecular sciences · 2026Article
- Inherited cancer syndromes in adult oncology: a referral guide based on malignant tumor and polyp features.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Expanding the Phenotypic Spectrum of DICER1 Syndrome: Case Report with Overgrowth, Macrocephaly, Multinodular Goiter, and Lung Cyst.Children (Basel, Switzerland) · 2026Article
- Preliminary investigation of the clinical value of thoracic ultrasound in pediatric pleuropulmonary blastoma: a comparative analysis with computed tomography and pathology.BMC pulmonary medicine · 2026Article
- Pleuropulmonary blastoma and the challenge of distinguishing the cystic form (type I) from other congenital lung malformations.Pediatric radiology · 2026Review
- Development and pilot testing of AYA-RISE, a risk information and screening education intervention for adolescents and young adults with cancer risk syndromes.Familial cancer · 2026Article
- Non-cell-autonomous tumor promotion in DICER1 cancer predisposition.Developmental cell · 2026Article
- Hereditary cancer syndromes with gynecological cancer risk: focus on prevention strategies.Frontiers in oncology · 2026Review
- Testing for hereditary cancer genes in men: a missed opportunity for cancer prevention.Frontiers in oncology · 2026Article
- MosaicFrontiers in oncology · 2026Article
- A contemporary overview of multiple endocrine neoplasia syndromes: MEN syndromes 1-5 and beyond.Endocrine oncology (Bristol, England) · 2026Review
- Cystic wilms tumor, cystic partially differentiated nephroblastoma, or cystic nephroma? A case report and review of the literature.Urology case reports · 2025Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 13 institutions in 4 countries.
Kris Ann P SchultzInternational Pleuropulmonary Blastoma Registry, Children's Minnesota, Minneapolis, Minnesota. krisann.schultz@childrensmn.org.
Gretchen M WilliamsInternational Pleuropulmonary Blastoma Registry, Children's Minnesota, Minneapolis, Minnesota.
Junne KamiharaPediatric Oncology, Dana-Farber Cancer Institute, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Solid Tumor Programs, Boston, Massachusetts.
Douglas R StewartClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Anne K HarrisInternational Pleuropulmonary Blastoma Registry, Children's Minnesota, Minneapolis, Minnesota.
Andrew J BauerDivision of Endocrinology and Diabetes, Pediatric Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Joyce TurnerCancer Genetic Counseling Program, George Washington University, Children's National Medical Center, Washington, D.C.
Rachana ShahDivision of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Katherine SchneiderDana-Farber Cancer Institute, Center for Cancer Genetics and Prevention, Boston, Massachusetts.
Kami Wolfe SchneiderHematology, Oncology, and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, Colorado.
Ann Garrity CarrWestat, Rockville, Maryland.
Laura A HarneyWestat, Rockville, Maryland.
Shari BaldingerVirginia Piper Cancer Institute, Allina Health, Minneapolis, Minnesota.
A Lindsay FrazierPediatric Oncology, Dana-Farber Cancer Institute, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Solid Tumor Programs, Boston, Massachusetts.
Daniel OrbachSIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), Institut Curie, Paris, France.
Dominik T SchneiderClinic of Pediatrics, Municipal Hospital Dortmund, Dortmund, Germany.
David MalkinDivision of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Louis P DehnerDivision of Anatomic Pathology, Lauren V. Ackerman Laboratory of Surgical Pathology, Barnes-Jewish and St. Louis Children's Hospitals, Washington University Medical Center, St. Louis, Missouri.
Yoav H MessingerInternational Pleuropulmonary Blastoma Registry, Children's Minnesota, Minneapolis, Minnesota.
D Ashley HillDepartment of Pathology, Center for Cancer and Immunology Research, Children's National Medical Center, Washington D.C.
Children’s Minnesota - St. Paul Hospital · USChildren's Hospital Colorado · USChildren's National · USDana-Farber Cancer Institute · USWestat (United States) · USAllina Health · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USInstitut Curie · FRKlinikum Dortmund · DENational Cancer Institute · USSt. Louis Children's Hospital · USUniversity of Toronto · CA
Funding
Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8MDICER1 and the Pleuropulmonary Blastoma Family Cancer SyndromeR01CA143167 · NCI · CHILDREN'S RESEARCH INSTITUTE · PI HILL, DANA ASHLEY · 2010 to 2020
$3.7MNCI NIH HHS R01 CA143167
Abstract
Pathogenic germline
Indexed as
Genetic Association StudiesGenetic Predisposition to DiseaseAlgorithmsDEAD-box RNA HelicasesDisease ManagementFemaleGenetic TestingGenotypeGlobal HealthHumansInheritance PatternsMass ScreeningMutationNeoplastic Syndromes, HereditaryPenetrancePrenatal DiagnosisDEAD-box RNA HelicasesDICER1 protein, humanRibonuclease III
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT00565903ClinicalTrials.gov
NCT03382158ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.