ArticleThe Journal of experimental medicine2018
Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors.
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Runx-CBFβ regulates the development of tolerogenic Thetis cells.Nature immunology · 2026Article
- RUNX proteins and CBFβ create an interconnected network of transcriptional regulation in the male germline†.Biology of reproduction · 2026Article
- Pathways and mechanisms of CD4Trends in immunology · 2024Review
- Downregulation of chemokine receptor 9 facilitates CD4Nature communications · 2023Article
- Cbf-β is required for the development, differentiation, and function of murine mucosal-associated invariant T cells.Cellular & molecular immunology · 2022Article
- An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.Immunity · 2020Article
- Review
- The Roles of RUNX Family Proteins in Development of Immune Cells.Molecules and cells · 2020Review
- Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming RorγtLife science alliance · 2020Article
- Transcription Factors in the Development and Function of Group 2 Innate Lymphoid Cells.International journal of molecular sciences · 2019Review
- Differential Requirement ofFrontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multipotent hematopoietic progenitors must acquire thymus-homing capacity to initiate T lymphocyte development. Despite its importance, the transcriptional program underlying this process remains elusive. Cbfβ forms transcription factor complexes with Runx proteins, and here we show that Cbfβ2, encoded by an RNA splice variant of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.