ArticlePediatric rheumatology online journal2018
Coexistent sickle-cell anemia and autoimmune disease in eight children: pitfalls and challenges.
Article in Pediatric rheumatology online journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Prevalence of autoimmune diseases in patients with sickle cell disease: a single center retrospective analysis.Haematologica · 2024Article
- Immune Cell Profiles of Patients with Sickle Cell Disease during Parvovirus B19-Induced Transient Red Cell Aplasia.Vaccines · 2024Article
- Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions.Nutrients · 2024Review
- Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association?Reumatologia · 2024Article
- Coexistent sickle cell anemia and autoimmune hemolytic anemia in two adolescents.Einstein (Sao Paulo, Brazil) · 2024Article
- A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia.Biomedicines · 2023Review
- Article
- Liver Disease and Sickle Cell Disease: Auto-Immune Hepatitis more than a Coincidence; A Systematic Review of the Literature.Mediterranean journal of hematology and infectious diseases · 2023Review
- Risk of vaso-occlusive episode after exposure to corticosteroids in patients with sickle cell disease.Blood · 2022Article
- Is the treatment of inflammatory arthritis different in sickle cell disease?Turkish journal of medical sciences · 2022Article
- Rheumatoid Arthritis Veiled by Sickle Beta-Thalassemia: A Rare Immunological Association Delaying Diagnosis.Cureus · 2021Article
- Coexistence of Relapsing Polychondritis and Sickle Cell Disease in a Child.Case reports in rheumatology · 2021Article
- Optimizing the management of chronic pain in sickle cell disease.Hematology. American Society of Hematology. Education Program · 2020Review
- Hepatobiliary Complications in Children with Sickle Cell Disease: A Retrospective Review of Medical Records from 616 Patients.Journal of clinical medicine · 2019Article
- Innate-like T cells in children with sickle cell disease.PloS one · 2019Article
- Rheumatic Manifestations of Haemoglobinopathies.Current rheumatology reports · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with sickle cell disease (SCD) present a defective activation of the alternate complement pathway that increases the risk of infection and is thought to predispose to autoimmune disease (AID). However, coexisting AID and SCD is rarely reported, suggesting possible underdiagnosis due to an overlapping of the symptoms. STUDY
designAmong 603 patients with SCD followed between 1999 and June 2016, we retrospectively searched for patients with coexisting SCD and AID.
resultsWe identified 8 patients aged from 7 to 17 years diagnosed with AID; juvenile idiopathic arthritis (n = 3), systemic lupus erythematosus (n = 2), Sjögren's syndrome (n = 1) and autoimmune hepatitis (n = 2). The diagnosis of AID was often delayed due to similarities of the symptoms with those of SCD. Patients treated with steroids experienced multiple vaso-occlusive crises and received prophylactic chronic blood transfusions when it was possible. Tolerance to other immunosuppressive and biological treatments, such as anti-TNF agents, was good. A remission of AID was achieved in 4 patients, without worsening the course of the SCD. One patient underwent a geno-identical hematopoietic stem cell transplantation that cured both diseases. Another one underwent a successful liver transplantation.
conclusionCoexistence of AID and SCD generates diagnostic and therapeutic challenges. Early diagnosis of AID is important to define the best treatment, which may include targeted biological therapy.
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