ArticleEnvironmental health : a global access science source2018
Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study.
Article in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06316609 (Prenatal Exposure to Emerging Contaminants and Offspring's Atopic Dermatitis), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prenatal Exposure to Emerging Contaminants and Offspring's Atopic Dermatitis (PECCAD)
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Perfluoroalkyl compound levels in breast milk of mothers in Riyadh, Kingdom of Saudi Arabia.Scientific reports · 2026Article
- [Per- and polyfluoroalkyl substances-"forever chemicals" and skin].Dermatologie (Heidelberg, Germany) · 2026Review
- Managing PFAS in Sewage Sludge: Exposure Pathways, Impacts, and Treatment Innovations.Journal of xenobiotics · 2025Review
- Per- and Polyfluoroalkyl Substance-Induced Skin Barrier Disruption and the Potential Role of Calcitriol in Atopic Dermatitis.International journal of molecular sciences · 2025Article
- Perfluorononanoic Acid (PFNA) Exacerbates Atopic Dermatitis by Inducing Inflammation in Mice.Toxics · 2025Article
- The Impact of Perfluoroalkyl Substances on the Clinical Manifestations of Primary Sjögren Syndrome.Toxics · 2025Article
- A review of pharmaceutical and personal care products and atopic dermatitis based on epidemiological and basic research findings.Frontiers in public health · 2025Review
- Prenatal exposure to endocrine-disrupting chemicals and childhood atopic dermatitis: epidemiological evidence.Frontiers in microbiology · 2025Review
- Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion.Environmental research · 2024Article
- Early-life risk factors which govern pro-allergic immunity.Seminars in immunopathology · 2024Review
- Prenatal Factors in the Development of Allergic Diseases.International journal of molecular sciences · 2024Review
- Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers.Journal of clinical medicine · 2023Review
- Advancing pediatric care before birth.Frontiers of medicine · 2023Article
- The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review.Journal of clinical medicine · 2023Review
- Prenatal Maternal Risk Factors Contributing to Atopic Dermatitis: A Systematic Review and Meta-Analysis of Cohort Studies.Annals of dermatology · 2023Article
- Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands.Journal of immunotoxicology · 2021Article
- The prevalence and year lived with disability of atopic dermatitis in China: Findings from the global burden of disease study 2019.The World Allergy Organization journal · 2021Article
- Perfluoroalkyl substances and immune cell counts in adults from the Mid-Ohio Valley (USA).Environment international · 2021Article
- Environmental exposure during pregnancy and the risk of childhood allergic diseases.World journal of pediatrics : WJP · 2021Review
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPerfluoroalkyl and polyfluoroalkyl substances (PFASs) have been reported to suppress immune function. However, previous studies on prenatal exposure to PFASs and allergic disorders in offspring provided inconsistent results. We aimed to examine the association between prenatal exposure to PFASs and childhood atopic dermatitis (AD) in offspring up to 24 months of age.
methodsA prospective birth cohort study involving 1056 pregnant women was conducted in two hospitals in Shanghai from 2012 to 2015. Prenatal information was collected by an interview with the women and from medical records. Fetal umbilical cord blood was collected at birth. Cord blood plasma PFASs were measured. Children were followed at 6, 12 and 24 months and information on the development of AD was recorded. AD was diagnosed by 2 dermatologists independently based on the questionnaires. Multiple logistic regression was used to compute odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between AD and each PFASs, adjusting for potential confounders.
resultsA total of 687 children completed a 2-year follow-up visit and had PFASs measurement. AD was diagnosed in 173 (25.2%) children during the first 24 months. In female children, a log-unit increase in perfluorooctanoic acid (PFOA) was associated with a 2.1-fold increase in AD risk (AOR 2.07, 95% CI 1.13-3.80) after adjusting for potential confounders. The corresponding risk was 2.22 (1.07-4.58) for perfluorononanoic acid (PFNA). The highest PFOA quartile was significantly associated with AD (2.52, 1.12-5.68) compared with the lowest quartile. The highest quartile of PFNA, perfluorodecanoic acid (PFDA) and perfluorohexane sulfonic acid (PFHxS) were associated with AD with AOR (95% CI) being 2.14 (0.97-4.74), 2.14 (1.00-4.57), and 2.30 (1.03-5.15), respectively. Additionally, the second quartile of perfluorododecanoic acid (PFDoA) was associated with a 3.2-fold increase in AD risk (3.24, 1.44-7.27). However, no significant associations were found in male children.
conclusionsPrenatal exposure to PFOA, PFDA, PFDoA and PFHxS significantly increased the risk of childhood AD in female children during the first 24 months of life. In addition, the associations between AD with prenatal exposure to PFNA were close to statistical significance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.