ArticleNutrients2018
Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA²LEN Study.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of preserved ratio impaired spirometry and restrictive spirometry pattern in the general population: a systematic review and multi-level meta-analysis of studies from multiple countries.Journal of global health · 2026Pooled it
- The Effects of Fruit-Derived Polyphenols on Cognition and Lung Function in Healthy Adults: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Pooled it
- From Chronic Inflammation to Remodeling: Anthocyanins in the Context of Asthma Management.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Associations between life's essential 8 and preserved ratio impaired spirometry.Scientific reports · 2025Article
- 10 practical priorities to prevent and manage serious allergic reactions: GAClinical and translational allergy · 2024Review
- Flavonoid intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a cohort study in the UK Biobank.The American journal of clinical nutrition · 2024Article
- Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Effects of 7-day polyphenol powder supplementation on cycling performance and lung function in an ozone-polluted environment.European journal of applied physiology · 2024Article
- Dietary antioxidants and flavonoids intake, and their association with inflammation and oxidative stress parameters in asthmatic women: a case-control study.Journal of clinical biochemistry and nutrition · 2024Article
- Heavy metal levels and flavonoid intakes are associated with chronic obstructive pulmonary disease: an NHANES analysis (2007-2010 to 2017-2018).BMC public health · 2023Article
- Dietary Polyphenols-Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions.Nutrients · 2023Review
- The Possible Role of Food and Diet in the Quality of Life in Patients with COPD-A State-of-the-Art Review.Nutrients · 2023Review
- Plant Food Dyes with Antioxidant Properties and Allergies-Friend or Enemy?Antioxidants (Basel, Switzerland) · 2023Review
- Change in habitual intakes of flavonoid-rich foods and mortality in US males and females.BMC medicine · 2023Article
- Review ofJournal of food science and technology · 2023Review
- Flavonoid intakes inversely associate with COPD in smokers.The European respiratory journal · 2022Article
- Lung function, COPD and Alternative Healthy Eating Index in US adults.ERJ open research · 2021Article
- Household Food Insecurity, Lung Function, and COPD in US Adults.Nutrients · 2021Article
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce.
methodsA stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV₁) and FVC (FEV₁/FVC), FVC below lower limit of normal (FVC < LLN), and FEV₁/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA²LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes' procedure was used to test for multiple comparisons.
resultsA total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV₁/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes' procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction.
conclusionsThis population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.
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