Evidence map›Paper›PMID 29342962›Full record

ArticleInternational journal of molecular sciences2018

Functional Analyses of RUNX3 and CaMKIINα in Ovarian Cancer Cell Lines Reveal Tumor-Suppressive Functions for CaMKIINα and Dichotomous Roles for RUNX3 Transcript Variants.

Karolin Heinze, Daniel Kritsch, Alexander S Mosig, Matthias Dürst, Norman Häfner, Ingo B Runnebaum

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Karolin HeinzeDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. karolin.heinze@med.uni-jena.de.
Daniel KritschDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. daniel.kritsch@uni-jena.de.
Alexander S MosigDepartment of Biochemistry II, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. alexander.mosig@med.uni-jena.de.
Matthias DürstDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. matthias.duerst@med.uni-jena.de.ORCID 0000-0003-1235-1150
Norman HäfnerDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. norman.haefner@med.uni-jena.de.ORCID 0000-0002-7012-483X
Ingo B RunnebaumDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. ingo.runnebaum@med.uni-jena.de.
Jena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Epithelial ovarian cancer (EOC) is the most lethal cancer of the female reproductive system. In an earlier study, we identified multiple genes as hypermethylated in tumors of patients with poor prognosis. The most promising combination of markers to predict a patient's outcome was

Indexed as

Cell CycleCell Line, TumorCisplatinComputational BiologyCore Binding Factor Alpha 3 SubunitDrug Resistance, NeoplasmEctopic Gene ExpressionFemaleGene Expression Regulation, NeoplasticHumansIsoflavonesOvarian NeoplasmsPromoter Regions, GeneticProteinsTranscription, GeneticTumor Suppressor ProteinsCAMK2N1 protein, humanCisplatinCore Binding Factor Alpha 3 SubunitdichotomitinIsoflavonesProteinsRunx3 protein, humanTumor Suppressor ProteinsCaMKIINαepithelial ovarian cancerplatin resistanceRUNX3tumor suppressor

Identifiers

PMID29342962
PMCPMC5796200
OpenAlexW2784318301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.