Evidence map›Paper›PMID 29342849›Full record

ArticleToxins2018

Comparative Response of the Hepatic Transcriptomes of Domesticated and Wild Turkey to Aflatoxin B₁.

Kent M Reed, Kristelle M Mendoza, Juan E Abrahante, Roger A Coulombe

Open access · goldAbstract readComparative Study
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kent M ReedDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA. reedx054@umn.edu.ORCID 0000-0002-5002-1649
Kristelle M MendozaDepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA. mendo008@umn.edu.
Juan E AbrahanteUniversity of Minnesota Informatics Institute, University of Minnesota, Minneapolis, MN 55455, USA. abrah023@umn.edu.
Roger A CoulombeDepartment of Animal, Dairy and Veterinary Sciences, College of Agriculture, Utah State University, Logan, UT 84322, USA. roger@usu.edu.
University of Minnesota · USUtah State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The food-borne mycotoxin aflatoxin B₁ (AFB₁) poses a significant risk to poultry, which are highly susceptible to its hepatotoxic effects. Domesticated turkeys (

Indexed as

Aflatoxin B1AnimalsLiverMaleTranscriptomeTurkeysAflatoxin B1aflatoxin B1differential expressiondomesticated turkeyKey ContributionliverResults of this study support the hypothesis that the greater ability of wild turkeys to detoxify AFB1 is related to higher constitutive expression of GSTA3 coupled with an inherited (genetic) difference in functional expression in domesticated birds. Key differences in GSTA3 expression between the Eastern wild and domesticated turkeys is not unique to these genetic lines but is a broader phenomenon indicating lower fitness in domesticated birds. Results of RNA-seq analysis emphasize the differential response of these genetically distinct birds, demonstrating significant differences in expression of Phase I and Phase II genes and in genes important in toxic response.RNA-seqwild turkey

Identifiers

PMID29342849
PMCPMC5793129
OpenAlexW2784239997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.