ArticleEndoscopy2018
Detection of early neoplasia in Barrett's esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.
Article in Endoscopy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Transforming Gastrointestinal Diagnosis with Molecular Endoscopy: Challenges and Opportunities.International journal of molecular sciences · 2025Review
- Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Application of near-infrared fluorescence imaging in theranostics of gastrointestinal tumors.Gastroenterology report · 2023Review
- Computer-Aided Diagnosis by Tissue Image Analysis as an Optical Biopsy in Hysteroscopy.International journal of molecular sciences · 2022Review
- CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett's esophagus.EJNMMI research · 2022Article
- Is Computer-Assisted Tissue Image Analysis the Future in Minimally Invasive Surgery? A Review on the Current Status of Its Applications.Journal of clinical medicine · 2021Review
- First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett's-related neoplasia.Journal of biomedical optics · 2021Article
- Microenvironmental modulation of the developing tumour: an immune-stromal dialogue.Molecular oncology · 2021Review
- Advances in optical gastrointestinal endoscopy: a technical review.Molecular oncology · 2021Review
- Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy.Biomedical optics express · 2021Article
- Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus.Cancer research · 2021Article
- Novel Ex Vivo Model to Examine the Mechanism and Relationship of Esophageal Microbiota and Disease.Biomedicines · 2021Article
- BanLec-eGFP Chimera as a Tool for Evaluation of Lectin Binding to High-Mannose Glycans on Microorganisms.Biomolecules · 2021Article
- Is Malignant Potential of Barrett's Esophagus Predictable by Endoscopy Findings?Life (Basel, Switzerland) · 2020Review
- Lectins in Cervical Screening.Cancers · 2020Article
- Deep learning applied to hyperspectral endoscopy for online spectral classification.Scientific reports · 2020Article
- Molecular endoscopic imaging: the future is bright.Therapeutic advances in gastrointestinal endoscopyReview
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND STUDY
aimsEndoscopic surveillance for Barrett's esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting.
methodsConsecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were recruited. Freshly collected EMR specimens were sprayed at the bedside with fluorescent lectin and then imaged. Punch biopsies were collected from each EMR under NIR light guidance. We compared the fluorescence intensity from dysplastic and nondysplastic areas within EMRs and from punch biopsies with different histological grades.
results29 EMR specimens were included from 17 patients. A significantly lower fluorescence was found for dysplastic regions across whole EMR specimens (
conclusionLectin-based NIR imaging can differentiate dysplastic from nondysplastic Barrett's mucosa ex vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.