Evidence map›Paper›PMID 29342370›Full record

ArticleJournal of dental research2018

FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate.

J Xu, Z Huang, W Wang, X Tan, H Li, Y Zhang, W Tian, T Hu, Y P Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. The Influence of theAnimals : an open access journal from MDPI · 2026
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  16. Article
  17. [Research Progress of Fibroblast Growth Factor 8's Role in the Regulation of Bone Development and Homeostasis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Review
  18. Review
  19. Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

J Xu1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, and Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
Z Huang3 Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, P.R. China.
W Wang3 Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, P.R. China.
X Tan3 Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, P.R. China.
H Li3 Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, P.R. China.
Y Zhang3 Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, P.R. China.
W Tian4 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
T Hu1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, and Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
Y P Chen2 Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA.
Fujian Normal University · CNState Key Laboratory of Oral Diseases

Funding

Role of BMP and Wnt signaling in early tooth developmentR01DE024152 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, YIPING · 2014 to 2018
$1.9M
Molecular patterning of the hard palate during palatogenesisR01DE026482 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, YIPING · 2017 to 2021
$1.8M
NIDCR NIH HHS R01 DE024152NIDCR NIH HHS R01 DE026482
6 · The paper itself

Abstract

Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulate the osteogenic cell fate in the developing palate remain unclear. In the present study, we investigated the potential role of FGF signaling in osteogenic fate determination of the palatal mesenchymal cells. We showed that locally activated FGF8 signaling in the anterior palate using a Shox2

Indexed as

Cell LineageAnimalsCell DifferentiationFibroblast Growth Factor 8MiceOsteogenesisPalate, HardReverse Transcriptase Polymerase Chain ReactionFgf8 protein, mouseFibroblast Growth Factor 8cell transdifferentiationchondrogenesisfibroblast growth factorsmorphogenesisneural crestosteogenesis

Identifiers

PMID29342370
PMCPMC5958370
OpenAlexW2785646883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.